The patient's serum alcohol level was negative and there was also no reported drug or alcohol history. Urine toxicology was only positive for benzodiazepine and opiate, and her valproic acid level was 75 mcg/ml and within the therapeutic range. The patient was found to have variable level of...
Association of valproic acid and its main metabolites’ plasma concentrations with clinical outcomes among epilepsy patients: a 10-year retrospective study based on therapeutic drug monitoring. Drug Metab Dispos. 2024;52(3):210–7. Article CAS PubMed Google Scholar Guo J, Liu Y, Kong L, Sun...
The therapeutic effect appears to correlate better with dosage per kilogram body weight than with the actual plasma concentrations. Routine monitoring of valproate plasma concentrations in epileptic patients seems to be of limited value. 展开 关键词: Keywords Valproic acid Epilepsy Plasma concentrations ...
In the literature, plasma is reported to be around 90% for levels within the therapeutic range. In our patient plasma was around 50% after treatment with haemodialysis.: These findings make haemodialysis in intoxication a sensible therapeutic option with increasing efficiency when plasma concentration ...
Bipolar major depression (alternative agent) (mono- or adjunctive therapy) (off-label use): Based on limited data: Oral: Initial: 500 to 750 mg/day; increase by 250 to 500 mg every 1 to 3 days to reach desired clinical effect and therapeutic serum concentration; therapeutic serum levels ...
Potential therapeutic agents for ischemic white matter damage Mahmoud I.Youssef, ...Wei-WeiHu, inNeurochemistry International, 2021 4.4.5Valproic acid Valproic acid(2-n-propylpentanoic acid) is an anti-epileptic drug which has also been used for bipolar, migraine and anxiety disorders. Valproic ac...
Valproic acid treatment may be harmful in non-dominant forms of retinitis pigmentosa I read with great excitement the article 'Therapeutic Potential of Valproic Acid for Retinitis Pigmentosa', by Clemson et al Patients who received oral valproic acid (VPA) were reported to have improvement in Goldma...
Valproic acid as a therapeutic agent for head and neck squamous cell carcinomas Purposes Here we investigate if valproic acid (VA) can enhance the efficacy of commonly used therapies for head and neck squamous cell carcinomas (HNSCC) a... RB Erlich,D Rickwood,WB Coman,... - 《Cancer Che...
Therapeutic Potential Valproic acid has been shown to be effective and well tolerated in the treatment of patients with bipolar and schizoaffective disorders, including those resistant to lithium and carbamazepine. When given alone or (more commonly) in combination with other agents in noncomparative...
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