We determined the blood ammonia level of epileptic patients in relation to valproic acid (VPA) therapy. A total determination of 256 specimens obtained from 174 cases were analyzed. The materials were assigned to the following three treatment groups: (a) VPA-monotherapy, (b) VPA-polytherapy and...
Gabapentin, valproic acid, and ethanol intoxication: elevated blood levels with mild clinical effects. J Toxicol Clin Toxicol 1996;34(4):437-9.Fernandez MC, Walter FG, Petersen LR, Walkotte SM (1996) Gabapentin, valproic acid, and ethanol intoxication: elevated blood levels with mild clinical ...
Association of valproic acid and its main metabolites’ plasma concentrations with clinical outcomes among epilepsy patients: a 10-year retrospective study based on therapeutic drug monitoring. Drug Metab Dispos. 2024;52(3):210–7. Article CAS PubMed Google Scholar Guo J, Liu Y, Kong L, Sun...
andbone marrow suppression.237The Vdofvalproic acidis 0.2 L/kg but will increase with toxic ingestion.238It is highly protein bound at 95% with therapeutic levels, but theprotein bindingdecreases with a toxic ingestion, older age, or liver or renal disease and has been shown to be as low ...
Since plasma protein-bound valproate is available for uptake by brain, the major factor underlying the diminished distribution of the drug in brain appears to be the asymmetric transport properties of the BBB to valproic acid. 展开 关键词: Blood-brain barrier polarity Valproic acid Serum protein ...
However, therapeutic valproate serum concentration for most patients with absence seizures is considered to range from 50 to 100 mcg/mL. Some patients may be controlled with lower or higher serum concentrations [see Clinical Pharmacology ( 12.3)] . As the Valproic acid dosage is titrated upward,...
Bipolar major depression (alternative agent) (mono- or adjunctive therapy) (off-label use): Based on limited data: Oral: Initial: 500 to 750 mg/day; increase by 250 to 500 mg every 1 to 3 days to reach desired clinical effect and therapeutic serum concentration; therapeutic serum levels ...
• Monitor valproate blood level; therapeutic range is 50 to 100 mcg/ml. Patient teaching • Instruct patient to take with food to minimize GI upset. • Tell patient taking extended-release tablets or valproic acid capsules to swallow them whole without chewing or breaking. • Inform pati...
Therapeutic Potential Valproic acid has been shown to be effective and well tolerated in the treatment of patients with bipolar and schizoaffective disorders, including those resistant to lithium and carbamazepine. When given alone or (more commonly) in combination with other agents in noncomparative...
STAVZOR (valproic acid) delayed release capsules are administered orally, and must be swallowed whole. The recommended initial dose is 750 mg daily in divided doses. The dose should be increased as rapidly as possible to achieve the lowest therapeutic dose which produces the desired clinical effec...