Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. ChemeGen 作...
After the administration of meropenem, the patient's number of seizures increased and the serum trough level of valproic acid decreased to 4.3 渭g/ml. The valproic acid levels turned back to normal range after switching to a carbapenem antibiotic. Conclusion: ...
Surprisingly, despite years of research,valproic acid'smechanism of action has remained unclear. Here, we have provided insight into valproic acid's putative mechanism of action. Further, we used a simple model system,Dictyostelium, to screen a range of medium-chain fatty acids and their derivativ...
(n=45) after a single valproic acid dose; the mean time to achieve maximum pain relief was 63 ± 31 minutes (range: 15 to 160 minutes) after a single dose of valproic acid; maximum pain reduction following a repeat 500 mg dose was observed at 124 ± 62 minutes (range: 20 to 250 ...
Nonetheless, the PLT counts were still within the normal range, and none of the patients had a PLT count < 100 × 109/L. After the long-term VPA monotherapy, the serum calcium level in the ≥ 3 years group was significantly lower than that in the < 1 year group (...
Valproic acid is a carboxylic acid designated as 2–propylpentanoic acid. It is also known as dipropylacetic acid. Valproic acid (pKa 4.8) has a molecular weight of 144 and occurs as a colorless liquid with a characteristic odor. It is slightly soluble in water (1.3 mg/ml) and very solu...
However, therapeutic valproate serum concentration for most patients with absence seizures is considered to range from 50 to 100 mcg/mL. Some patients may be controlled with lower or higher serum concentrations [see Clinical Pharmacology ( 12.3)] . As the Valproic acid dosage is titrated upward,...
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Valproic acid (VPA) poisoning is responsible for life-threatening neurological and metabolic impairments. Despite only low-level evidence of effectiveness, L-carnitine has been used for years to prevent or reverse VPA-related toxicity. We aimed to evaluate the effects of L-carnitine used to treat ...
• Monitor valproate blood level; therapeutic range is 50 to 100 mcg/ml. Patient teaching • Instruct patient to take with food to minimize GI upset. • Tell patient taking extended-release tablets or valproic acid capsules to swallow them whole without chewing or breaking. • Inform pati...