Valproic Acid (VPA) is an important drug for the treatment of several types of seizures because it has a wide spectrum of activity. Since VPA has an unusual nonlinear binding characteristic and a wide interindividual variation, monitoring of its free concentration can be helpful in patient manageme...
Valproic acidReactions Weekly -doi:10.2165/00128415-199605970-00036Springer International PublishingReactions Weekly
carbamazepine, phenobarbital, primidone) can decrease plasma concentrations of valproic acid. Adjustment of valproic acid dosage may therefore be necessary when such drugs are initiated or withdrawn. Salicylates increase free and total plasma valproate concentrations by inhibition of valproate metabolism and ...
Define valproic acid. valproic acid synonyms, valproic acid pronunciation, valproic acid translation, English dictionary definition of valproic acid. n. An anticonvulsive drug, C8H15NaO2, given orally and by injection to treat epilepsy. American Heritage
valproic acid was associated with other antiepileptic drugs (Rasalam et al., 2005). In a large population-based study on Danish people,Christensen et al. (2013)found 508 children exposed in utero to valproic acid and 2136 to other anticonvulsant drugs over a total of 655,615 eligible ...
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Vd: Total valproate: 11 L/1.73 m2; Free valproate 92 L/1.73 m2MetabolismExtensively hepatic via glucuronide conjugation (30% to 50% of administered dose) and 40% via mitochondrial beta-oxidation; other oxidative metabolic pathways occur to a lesser extent.Excretion...
PND: Postnatal day SD: Standard diet SI: Sociability index VPA: Valproic acid VTA: Ventral tegmental area vGAT: Vesicular GABAergic transporter vGLUT: Vesicular glutamatergic transporter v/v: Volume/volume w/v: Weight/volume w/w: Weight/weight ...
The present invention relates to the use of valproic acid and derivatives thereof as an inhibitor of histone deacetylases. The invention also concerns the use of those compounds for the manufacture
Valproic acid: preclinical and clinical studies The anti-epileptic valproic acid (2-propylpentanoic acid, VPA), an 8-carbon, branched-chained fatty acid, has HDAC inhibitory activity. Independent of this property, it is being used as an anticonvulsant agent and is clinically effective as a mood...