The absolute recovery of valproic acid was over 82% in the studied range of concentrations in both matrixes. Valproic acid was found to be stable in both matrixes at the assayed conditions. This method has shown to be suitable for the analysis of free and total valproic acid concentrations in...
Related to valproic acid:Divalproex,Sodium valproate val·pro·ic acid (văl-prō′ĭk) n. Ananticonvulsivedrug,C8H15NaO2,givenorallyandbyinjectiontotreatepilepsy. [val(eric acid)+pro(pyl)+-ic.] AmericanHeritage®DictionaryoftheEnglishLanguage,FifthEdition.Copyright©2016byHoughtonMifflinHarcourt...
Valproic Acid (VPA) is an important drug for the treatment of several types of seizures because it has a wide spectrum of activity. Since VPA has an unusual nonlinear binding characteristic and a wide interindividual variation, monitoring of its free concentration can be helpful in patient manageme...
The mice are randomLy assigned to two groups, the Valproic acid (n=6) and control (n=6) groups. When the tumors are appr 200 mm3?in size at appr 10 days post-implantation, 0.2 mL Valproic acid (500 mg/kg body weight) or 0.2 mL saline is injected intraperitoneally every day. ...
Liver damage, coagulopathy, hyperammonemia, fracture, menstrual disorder and amenorrhea are the most concerned adverse drug reactions of valproic acid (VPA). This study was aimed to retrospectively investigate the incidence of adverse drug reactions of VPA in the real world and its association with th...
Valproic acidis a branch-chain fatty acid, 2-propylpentanoic acid. Its antiseizure effects were discovered while using it as a solvent to dissolve a series of potential newantiepileptic drugs[1]. Subsequently,valproic acidand its salt,sodium valproate, have become widely used as broad-spectrum an...
Free carnitine levels in plasma and heart were also decreased. Enzyme activities of various acyl-CoA dehydrogenases, which are involved in fatty acid oxidation, decreased moderately in heart (5779%), and slightly in liver (7895%). The most prominent effects were observed in mRNA levels involved ...
drugs are initiated or withdrawn. Salicylates increase free and total plasma valproate concentrations by inhibition of valproate metabolism and displacement of valproate from plasma binding sites. In contrast with other antiepileptic agents, valproic acid does not impair the efficacy of oral contraceptives....
The disposition of valproic acid (di-n-propylacetate; VA) has been studied after a single oral dose of a solution of 450 mg in 7 patients with alcoholic cirrhosis and in 4 patients recovering from acute hepatitis. The diagnosis was based on biochemical function tests and histological findings....
Package insert / product label Dosage form: capsule, liquid filled Drug class: Fatty acid derivative anticonvulsantsMedically reviewed by Drugs.com. Last updated on Dec 10, 2024.On This Page Indications and Usage Dosage and Administration Dosage Forms and Strengths Contraindications Warnings and Precau...