Valproic acid attenuates the expression of pro-inflammatory cytokines lipopolysaccharide-treated canine peripheral blood mononuclear cells (in vitro) and in a canine endotoxemia model (in vivo) Vet. Immunol. Immunopathol., 166 (2015), pp. 132-137 Google Scholar Su et al., 2021 B. Su, et al....
Valproic acid is a carboxylic acid designated as 2–propylpentanoic acid. It is also known as dipropylacetic acid. Valproic acid (pKa 4.8) has a molecular weight of 144 and occurs as a colorless liquid with a characteristic odor. It is slightly soluble in water (1.3 mg/ml) and very solu...
Valproic acid drug interactions (more detail)Test InteractionsMay cause a false-positive result for urine ketones (valproate partially eliminated as a keto-metabolite in the urine); may alter thyroid function testsAdverse ReactionsThe following adverse drug reactions and incidences are derived from ...
As the Valproic acid dosage is titrated upward, blood concentrations of phenobarbital and/or phenytoin may be affected [see Drug Interactions ( 7.2)] . Antiepilepsy drugs should not be abruptly discontinued in patients in whom the drug is administered to prevent major seizures because of the str...
Valproic acid, a simple branched-chain fatty acid, was originally developed for the treatment of epilepsy, but also has mood-stabilising, anxiolytic, antim
Blood was drawn to determine plasma zinc. The data were analyzed by using analysis of variance (Kruskal -Wallis test). The zinc concentration in the plasma of rats treated with valproic acid was significantly lower than those of the other groups on 16 GD (P=0.004). Some anomalies such as ...
Valproic acid详情 评价(0) 货号:ajci7090 CAS:99-66-1 别名:丙戊酸; VPA; 2-Propylpentanoic Acid 分子式:C8H16O2 分子量:144.21 纯度:>98% 溶解度:≥ 36mg/mL in Water, ≥ 29mg/mL in EtOH, ≥ 12.35mg/mL in DMSO 储存:Store at -20°C ...
Thus the non-teratogenic analogues valpromide (VPM), in which the carboxyl group is modified to an amide, and 2-methyl-2-propylpentenoic acid (2M2P), in which a methyl group is added to the α-carbon, do not cause neural tube defects in mouse embryos, and neither of these compounds ...
Recently, a new rodent model of autism was created by exposure of rat fetuses to valproic acid (VPA) on the 12.5th day of gestation (VPA rats). The model has striking anatomical, pathological, and etiological similarities to human data; however, it has not been characterized behaviorally. In...
Valproic acid详情 评价(0) 货号:ajci7090 CAS:99-66-1 别名:丙戊酸; VPA; 2-Propylpentanoic Acid 分子式:C8H16O2 分子量:144.21 纯度:>98% 溶解度:≥ 36mg/mL in Water, ≥ 29mg/mL in EtOH, ≥ 12.35mg/mL in DMSO 储存:Store at -20°C ...