然而,V-ATPase a亚基的各亚型在小胶质细胞发育过程中所扮演的角色,以及其在吞噬体成熟方面的作用尚未被明确阐明。 近日,华南理工大学徐进教授团队与张文清教授团队合作在Autophagy杂志上发表题为The different roles of V-ATPase a subunits ...
产品活性:Bafilomycin A1 (BafA1) 是特异性,可逆的 V-ATPase 抑制剂,IC50 值为 4-400 nmol/mg。Bafilomycin A1,大环内酯类抗生素, 是一种自噬 (autophagy) 晚期阶段抑制剂。Bafilomycin A1 阻断自噬体与溶酶体的融合,并抑制培养细胞溶酶体中的酸化和蛋白质降解。Bafilomycin A1 也诱导调亡 (apoptosis)。生物活...
Bafilomycin A1,中文名巴佛洛霉素 A1 或巴菲霉素 A1 ,简称 Baf A1 ,大环内酯类抗生素,是特异性、可逆的 V-ATPase 抑制剂,也是一种 自噬(autophagy)晚期阶段抑制剂。它能够阻断自噬体与溶酶体的融合,并抑制细胞溶酶体中的酸化和蛋白质降解。 Related Tags: buy Bafilomycin A1 | purchase Bafilomycin A1 | Bafilo...
Chloroquine phosphate (Aralen phosphate) 是广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。它是autophagy 和toll-like receptors 抑制剂,有效抑制SARS-CoV-2(COVID-19) 感染 (EC50=1.13 μM)。 AntibioticAutophagyHIV ProteaseParasiteSARS-CoVTLR ¥ 298 ...
To understand the role of autophagy in the pathogenesis of glial tumors in vivo, we used an established Drosophila melanogaster model of glioma based on overexpression in larval glial cells of an active human EGFR and of the PI3K homolog Dp110. Interestingly, the resulting hyperplastic glia ...
BafA1 is a well-known inhibitor of the last stages of autophagy [24, 27], a pathway deeply connected with lysosomal function that could promote cell death [28]. Therefore, we analyzed whether autophagy was affected after V-ATPase block. In BafA1-treated GSCs the autophagic markers LC3B-II ...
产品活性:Bafilomycin A1 (BafA1) 是特异性,可逆的 V-ATPase 抑制剂,IC50 值为 4-400 nmol/mg。Bafilomycin A1,大环内酯类抗生素, 是一种自噬 (autophagy) 晚期阶段抑制剂。Bafilomycin A1 阻断自噬体与溶酶体的融合,并抑制培养细胞溶酶体中的酸化和蛋白质降解。Bafilomycin A1 也诱导调亡 (apoptosis)。 生物...
As dysregulation of autophagy leads to a wide range of pathologies1, a large effort has been made to develop tools for a better understanding and control of the multistep autophagic process2. Autophagy begins with formation of an initiating membrane known as the phagophore, which may develop ...
OPEN Citation: Cell Death and Disease (2016) 7, e2330; doi:10.1038/cddis.2016.236 Official journal of the Cell Death Differentiation Association www.nature.com/cddis Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy Ying Gao1,5, Yajun Liu1,5, Liang Hong1, Zuolong ...
产品活性:Bafilomycin A1 (BafA1) 是特异性,可逆的 V-ATPase 抑制剂,IC50 值为 4-400 nmol/mg。Bafilomycin A1,大环内酯类抗生素, 是一种自噬 (autophagy) 晚期阶段抑制剂。Bafilomycin A1 阻断自噬体与溶酶体的融合,并抑制培养细胞溶酶体中的酸化和蛋白质降解。Bafilomycin A1 也诱导调亡 (apoptosis)。 生物...