Bafilomycin A1 属于大环内酯类抗生素,是一种 V-ATPase 抑制剂 (IC50=0.44 nM),具有特异性和可逆性。Bafilomycin A1 是自噬晚期阶段抑制剂,阻断自噬体与溶酶体的融合。Bafilomycin A1 也诱导凋亡。 规格价格库存数量 1 mg¥ 2,350现货 5 mg¥ 5,370现货 ...
V-ATPase inhibitor targets Ras-mutant cancersdoi:10.1038/d41573-022-00151-wSarah.CrunkhornNature Publishing Group UKNature reviews. Drug discovery
Concanamycin Ais a specific inhibitor of vacuolar type H+-ATPase activity (V-ATPase) and is capable of inducing apoptosis Disulfiram 97-77-8sc-205654 sc-205654A 50 g 100 g $46.00 $80.00 7 (1) Disulfiramis an ALDH and tumor cell growth inhibitor ...
V-ATPase inhibitors instead of lysosome inhibitors and ionophores block LC3 lipidation. Similar to Baf, concana- mycin A (ConA) is a well-studied V-ATPase inhibitor. Salicylihalamide A (SalA) is another mammalian-specific V-ATPase inhibitor, but has a distinct binding pattern compared with ...
arenaria might be a consequence of their vacuolar-type H+-ATPase (V-ATPase) inhibition activity; in fact α-methylene-γ-butyrolactone (1) and salicylaldehyde (12) produced an increased pH in lysosomal-like organelles on HeLa human cell line and this alteration was most likely related to a V...
The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor BafilomycinA1, lysosomal acidification is also thought to be required for fusion with incoming vesicles from the autophagic and endocy...
paracellular pathway and/or apical Cl−channels in stellate cells (Fig. 4). The critical role of the V-ATPase in transepithelial fluid secretion has been demonstrated by pharmacological studies with bafilomycin, a potent inhibitor of the V-ATPase. That is, in isolated Malpighian tubules of ...
We demonstrate for the first time that salicylihalamide A is a potent inhibitor of fully purified reconstituted V-ATPase from bovine brain, and have identified several similarly potent side chain modified derivatives, including salicylihalamide dimers 43−45. In combination, these studies have ...
However, when cells were pretreated with siRNAs to the Vod1 subunit of V-ATPase, the number of vacuoles per cell was reduced to 3.7 ± 1.8 (n = 90, P < 0.001). Treatment of cells with the V-ATPase inhibitor bafilomycin A1 also strongly inhibited the SNX10-induced vacuoles (1.1 ± ...
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