Comprising two main domains, V 1 and V 0 , V-ATPase drives the proton pump through ATP hydrolysis, sustaining the pH balance within the cell and organelles. In cancer cells, the enhanced activity of V-ATPase is closely associated with the proliferation and metastasis of tumor cells, and it...
:1004.0374( 2004) 02.0073.06V—ATPase:结构、功能及其在肿瘤细胞中的作用卢小东t,覃文新” ,杨胜利· ,z( 1江苏大学生命科学院,镇江212013:2上海交通大学医学院上海市肿瘤研究所癌基因及相关基因国家重点实验室,上海200032)摘要:真核细胞膜及管泡细胞器膜上广泛分布一种与H +主动转运有关的蛋白——v.ATPase。
the structure and function of V-ATPase, its impacts on cell glycolysis and even its effects in cancer cells will help to improve the further understanding of V-ATPase and investigate its effects in new tumor treatment programs, especially in targeted therapy research.[Key words] Vacuolar ATPase;...
Bafilomycin A1,中文名巴佛洛霉素 A1 或巴菲霉素 A1 ,简称 Baf A1 ,大环内酯类抗生素,是特异性、可逆的 V-ATPase 抑制剂,也是一种 自噬(autophagy)晚期阶段抑制剂。它能够阻断自噬体与溶酶体的融合,并抑制细胞溶酶体中的酸化和蛋白质降解。 关键词
and development [1]. V-ATPases are widely expressed in plasma and organelle membranes and are necessary to maintain lysosome pH gradients of cancer cells. The abnormal expression, mislocalization, and mutation of V-ATPase subunits or isoforms are tightly related to cancer progression, which makes...
We found that MET serves as a central component of the MTOR complex, independent of the PI3K–AKT cascade, and participates in MTOR activation by interacting with V-ATPase. We also demonstrate that the newly discovered MET–V-ATPase–MTOR signaling pathway more strongly suppresses liver cancer ...
V-ATPase在结肠癌中的表达及其临床意义 赵森林;孟镔;严东旺;张丽康;崔菲菲;陆惠军;陈健;彭志海 【摘要】Objective To explore the expression of V-ATPase in colon cancer and its clinical significance. Methods Detecting the expression of V-ATPase mRNA in 20 paired of colon tumor tissues and normal ...
The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells. J. Biol. Chem. 288, 32731–32741 (2013). Article CAS Google Scholar Nishisho, T. et al. The a3 isoform vacuolar type H+-ATPase promotes distant metastasis...
ATP6V1E1, also named as ATP6E, ATP6E2 and p31, belongs to the V-ATPase E subunit family. It is a subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic...
生物活性:Bafilomycin A1 (BafA1) 是一种特异性可逆的液泡 H+-ATPase(V-ATPase) 抑制剂,IC 值50值为 4-400 nmol/mg。 Bafilomycin A1 是一种大环内酯类抗生素,也用作晚期自噬抑制剂。 Bafilomycin A1 阻断自噬体-溶酶体融合并抑制培养细胞溶酶体中的酸化和蛋白质降解。 Bafilomycin A1 诱导细胞凋亡[1][2]...