Upon binding to 3p-RNA, RIG-I triggers downstream signaling through IFN regulatory factor 3 (IRF3), mitogen-activated protein kinase (MAPK), and NF-κB pathways via MAVS. We used 3pRNA to activate RIGI/MAVS signaling and found that the mRNA expression level of IFNβ, CXCL10, and ISG15 ...
HRESULTScriptStringFree( [in, out] SCRIPT_STRING_ANALYSIS *pssa ); パラメーター [in, out] pssa SCRIPT_STRING_ANALYSIS構造体へのポインター。 戻り値 成功した場合は、S_OKを返します。 関数は、成功しない場合は 0 以外の HRESULT 値を返します。 アプリケーションでは、SUCCEEDEDマクロと...
Lung cancer is one of the most common malignant tumors. Despite decades of research, the treatment of lung cancer remains challenging. Non-small cell lung
transcription-coupled nucleotide-excision repair ubiquitin-dependent protein catabolic process multicellular organism development maintenance of DNA methylation viral process protein deubiquitination negative regulation of NF-kappaB transcription factor activity protein stabilization regulation of sequence-specific DNA bi...
Mol. Cell 44, 325–340 (2011) Article CAS Google Scholar Kravtsova-Ivantsiv, Y., Cohen, S. & Ciechanover, A. Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-κB precursor. Adv. Exp. Med. Biol. 691, 95–106 ...
Download PDF Editorial Summary Lung cancer: Targeting a vicious circle Therapies targeting a molecular feedback loop involved in tumor growth may prove valuable for treating non-small-cell lung cancer. Fangbao Ding, Jianbing Huang, and co-workers at Shanghai Jiao Tong University in Shanghai, ...
6J). KEGG analysis of differentially expressed genes (DEGs) after METTL13 knockdown in PC3 cells revealed significant changes in the JAK-STAT and NFκB signaling pathways (Fig. 6K, Supplementary Table S6), which are crucial in determining the fate of prostate cancer stem cells [39,40,41]. ...
Download: Download high-res image (889KB) Download: Download full-size image Figure 1. Structure and Selectivity of XL188 (A) Structure-guided optimization of 1 led to USP7 inhibitor XL188. The enantiomer of XL188, XL203C, is 80-fold less active. (B) Dose-dependent inhibition of USP7...
Plasmid: pCMV3-N-FLAG-β-catenin Sino biological Cat# HG11279-NF Plasmid: FLAG-USP9X-pLenti-Tight-Puro Li et al.9 N/A Plasmid: HA- tagged ubiquitin Li et al.9 N/A Plasmid: FLAG-USP9X-N This paper N/A Plasmid: FLAG-USP9X-M This paper N/A Plasmid: FLAG-USP9X-C1 This paper ...