UnitéSamiUnitéBrahimUnitéDalelUnitéZourguiUnitéLazharUnitéLepesantUnitéJean-AntoineUnitéEBSCO_AspAustralian Journal of Basic & Applied SciencesSouid S, Brahmi D, Zourgui L, et al. Upr signaling in~ duces Jnk pathway activation in Drosophila melanogaster [J]. Australian Journal of Basic & ...
Introduction 1型糖尿病(T1DM)是由胰岛β细胞的自身免疫破坏导致内源性胰岛素分泌的绝对不足而引起的。由于目前没有治愈T1DM的策略,T1DM患者需要终生的胰岛素治疗以维持血糖稳态和预防并发症,对患者的生活及精神带来严重的负担。其中T1DM治疗的核心理论与修复受损的胰腺β细胞相关。 胰腺β细胞分泌适当的胰岛素以维持血糖稳...
(b) Model demonstrates the UPR signaling pathways are involved that respond to viral proteins, abiotic stress, SA binding proteins, and several other bacterial and fungal pathogens. The major branches are regulated by AGB1 and BAG7 that are known to activate cellular defenses involved in broad-sp...
Introduction 1型糖尿病(T1DM)是由胰岛β细胞的自身免疫破坏导致内源性胰岛素分泌的绝对不足而引起的。由于目前没有治愈T1DM的策略,T1DM患者需要终生的胰岛素治疗以维持血糖稳态和预防并发症,对患者的生活及精神带来严重的负担。其中T1DM治疗的核心理论与修复受损的胰腺β细胞相关。 胰腺β细胞分泌适当的胰岛素以维持血糖稳...
2022年7月5日,来自哈佛医学院的Umut Ozcan团队在Cell Metabolism杂志上发表了一篇题为FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity的文章,他们发现由XBP1转录调节的FK506结合蛋白11(FKBP11)水平在肥胖小鼠的肝脏中严重降低,而恢复FKBP11表达则能启动一种非典型UPR信号...
2022年7月5日,来自哈佛医学院的Umut Ozcan团队在Cell Metabolism杂志上发表了一篇题为FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity的文章,他们发现由XBP1转录调节的FK506结合蛋白11(FKBP...
Besides the excessivity/severity of ER stress and UPR activation, which other factors determine between adaptive and maladaptive UPR signaling in either the protection or death of neurons in AD? To what extent targeting components of maladaptive UPR could be effective in the alleviation of AD pathop...
Schwarz DS, Blower MD (2016) The endoplasmic reticulum: structure, function and response to cellular signaling. Cell Mol Life Sci 73(1):79–94 Article CAS PubMed Google Scholar Hetz C, Zhang K, Kaufman RJ (2020) Mechanisms, regulation and functions of the unfolded protein response. Nat Re...
and apoptosis [17,25]. The physiological role of the UPR is well defined from studies with animal models. In this section, we review the knockout models that have been developed for elucidating the role of the major UPR signaling molecules in pathophysiology, focusing mainly on metabolic disease...
UPR signaling is a complex signaling pathway, which is still being explored in many different cellular processes. Here, we demonstrate that FK506-binding protein 11 (FKBP11), which is transcriptionally regulated by XBP1s, is severely reduced in the livers of obese mice. Restoring hepatic FKBP11...