In contrast to the general belief, the crystallization of MIL-53 occurs via a solid-solid transformation mechanism, associated with the spontaneous release of monomeric aluminum. The role of DMF hydrolysis products, formate and dimethylamine, is established. Our study emphasizes the complexity of MOF...
Structurally, STAT3 mainly consists of the N-terminal domain (NTD), coiled-coiled domain, DNA binding domain (DBD), linker domain, Src homology 2 (SH2) domain and transactivation domain (TAD) [2]. The tyrosine residues 705 and serine residues 727 located in the C-terminal are considered tw...
Moreover, a recent study showed that dihydroartemisinin (DHA) could promote pyroptosis in ESCC cells through the PKM2/caspase-8/caspase-3/GSDME axis, providing new insights into the role of DHA in ESCC [251]. Moreover, treatment with cisplatin was proven to cause the activation of CAPN1 and...
Regulation of cell cytoskeleton and membrane mechanics by electric field: role of linker proteins Biophys. J. (2009) D.R. Merrill et al. Electrical stimulation of excitable tissue: design of efficacious and safe protocols J. Neurosci. Methods (2005)View...
states, one cannot rely on these expressions anymore to make a statement whether or not NGA is forbidden, indicating the crucial role of such phase transitions for the observation of NGA. Finally, Krause et al. even showed that NGA cannot take place at global thermodynamic equilibrium, but ...
survival [174]. B-type lamins can also enhance nuclear stiffness, thereby impacting confined migration [180,181]. Other factors contributing to nuclear rigidity include the chromatin organization [182] and the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex [183]. It is worth noting, ...
causing a frameshift and the transactivation domain is replaced with seven specific amino acids [8]. Conversely, STAT3β plays a tumor suppressive role due to the lack of transactivation domain and commonly predicts a favorable outcome in tumor patients [9]. A recent review of the literature repo...
As mentioned in the introduction, the VEGF receptor recognition (VEGF1–110) and the heparin binding (VEGF111–165) domains are connected by a linker sensitive to cleavage by plasmin. Plasmin plays a critical role in the VEGF signaling pathway by releasing the VEGF receptor recognition domain fro...
Furthermore, we provide a concise overview of the design and detection mechanisms employed in these DNA biosensors. Noteworthy advantages of DNA as a sensor component, including its programmable structure, reaction predictility, exceptional specificity, excellent sensitivity, and thermal stability, are ...