Design of inter-peptide linkerBivalent, bispecific single-chain antibody fusion protein construction appears to be a promising tool for tumor therapy. One of its drawbacks is that the function and activity of the fusion proteins have varied affinity and/or anti-tumor activity compared with the ...
Design of a versatile linker for solid phase peptide synthesis: Synthesis of C-terminal primary/seconary amides and hydrazides. Tetrahedron Lett. 1993, 34, 6599-6602.Ramage, R.; Irving, S. L.; McInnes, C. Design of a versatile linker for solid phase peptide synthesis: Synthesis of C-...
Design of inter-peptide linkerBivalent, bispecific single-chain antibody fusion protein construction appears to be a promising tool for tumor therapy. One of its drawbacks is that the function and activity of the fusion proteins have varied affinity and/or anti-tumor activity compared with the ...
The stereospecific synthesis of a cis-syn pyrimidine photodimer has been achieved using a cleavable linker. Removal of the linker is accomplished via bromine addition followed by a dual retro-Michael reaction.doi:10.1002/chin.199243189Doug Burdi...
The construction of recombinant fusion/chimeric proteins has been widely used for expression of soluble proteins and protein purification in a variety of fields of protein engineering and biotechnology. Fusion proteins are constructed by the linking of two protein domains with a peptide linker. The sel...
Aim: To design and synthesize a novel class of peroxisome proliferator-activated receptors (PPAR)α agonists, which is obtained by the combination of the classi- cal fibrate "head group", a linker with appropriate length and a chalcone. Methods: Thirty seven compounds were designed and identified...
The biological data showed the key role of the linker chain's length in inducing inhibitory properties, since only compounds 9 (α,β-mixture), bearing a two-carbon atom linker chain, maintained activity as trehalase inhibitors. A proper change in the glucosyl donor-protecting groups allowed the...
domain of the insulin receptor confirmed the key design features inspired by a dissociative transition state, and revealed that the linker takes part in the octahedral coordination of an active site Mg2+. These studies suggest a general strategy for the development of selective protein kinase ...
Tuberculosis (TB) is a highly contagious disease that mostly affects the lungs and is caused by a bacterial pathogen, Mycobacterium tuberculosis. The associated mortality rate of TB is much higher compared to any other disease and the situation is more w
of this vaccine candidate, CTL epitopes were linked by the AAY (Ala-Ala-Tyr) linkers, the GPGPG (Gly-Pro-Gly-Pro-Gly) linkers linked HTL epitopes, and the LBL epitopes were linked by KK (Lys-Lys) linkers110,111. Fynomer was added to the vaccine structure by the GPGPG linker between...