unique cell-surface protein phenotype distinguishes human small-cell from non-small-cell lung cancer
aMoreover, the unique protein structure offers the possibility of site-specific drug conjugation and targeting using various ligands modifying the surface of protein nanocarriers 而且,独特的蛋白质结构使用修改蛋白质nanocarriers的表面各种各样的ligands提供站点具体药物结合和瞄准的可能性 [translate] ...
CbpL implication in both resistance against killing by phagocytes and pneumococcal pathogenesis further postulate this surface-protein as relevant among the pathogenic arsenal of the pneumococcus. The Gram-positive bacterium Streptococcus pneumoniae is one of the most important human pathogens and a widely...
Membrane-associated guanylate kinase (MAGUK) proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. MAGUKs are characterized by three types of protein-protein interaction modules: the PDZ domain, the Src homology 3...
MED19, a component of the mediator complex and a co-regulator of the androgen receptor (AR), is pivotal in prostate cancer cell proliferation. MED19 has two isoforms: a full-length “canonical” and a shorter “alternative” variant. Specific antibodies
Bursal membranes had 4 unique proteins, 2 of which were still expressed in the circulating lymphocytes. Thymic membranes had 3 unique proteins, one of which was still expressed in the circulating lymphocytes. Membranes of circulating lymphocytes had one unique protein....
The structure of the M3 hydrogenase CpI has been studied by crystal structure analysis and in view of their relative locations, the distal [2Fe-2S]-subcluster and the His-ligated [4Fe-4S]-cluster are proposed to be initial electron acceptors [53]. Since the surface surrounding the His-liga...
By doing so we resolve a remarkable array of oligosaccharides, which are produced by two seemingly unrelated biosynthetic routes, and which modify the same surface-layer protein simultaneously. More intriguingly, the investigated strain also accomplished modulation of highly specialized sugars, supposedly ...
CTAs are multifunctional protein group with specific expression patterns in normal embryonic and adult cells and various types of cancer cells. CTAs are involved in regulating of the basic cellular processes during development, stem cell differentiation and carcinogenesis though the biological roles and ...
These properties of IgG4 have a blocking effect, either on the immune response or on the target protein of IgG4. In this Review, we discuss the unique structural characteristics of IgG4 and how these contribute to its roles in health and disease. We highlight how, depending on the setting...