The UGT1 gene subfamily consists of a number of UGTs that result from alternate splicing of multiple first exons and share common exons 2-5. The substrate specificities of the various isoforms have been examined in cultured cell experiments, and include bilirubin, amines, and planar and bulky ...
胃肠道UDP glucuronosyltransferases (UGTs)在抵御环境中外来生物的毒性作用中起着至关重要的作用。UGT1A8、UGT1A10等ugt主要在胃肠道组织中表达。 通过诱导UGT1A8和UGT1A10的表达,检测了雷洛昔芬在分化的Caco-2单分子膜中的II期代谢。本研究以黄芩中黄芩素、丹参素、黄芩素、黄芩素4种黄酮类化合物为模型化合物...
Knowledge about UGTs in different species, their regulation, and their tissue distribution will improve the risk assessment of carcinogens.doi:10.3109/10409239109081125BockKarl WalterTaylor & FrancisCrc Critical Reviews in BiochemistryBock, K. W. : Roles of UDP-glucuronosyltransferases in chemical ...
Summary UDP-glucuronosyltransferases (UGTs) catalyse a major phase-II reaction of drug metabolism converting lipophilic xenobiotics (bilirubin, steroid hormones, retinoids etc.), drugs and dietary plant constituents into hydrophilic and excretable conjugates. UGTs are bound to the endoplasmic reticulum ...
Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate.Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate.UDP-glucuronosyltr...
英文名称:UDP-Glucuronosyltransferases,UGTs 英文同义词:UDP-Glucuronosyltransferases,UGTs CAS号: 分子式: 分子量:0 EINECS号: 信息错误报告 您的Email: 按国家浏览UDP-Glucuronosyltransferases,UGTs国外供应商中国供应商 UDP-Glucuronosyltransferases,UGTs推荐供应商 ...
quinone oxidoreductase 1 (NQO1) targeting antitumor drug candidate in phase II clinical trials, is metabolically eliminated via NQO1 mediated quinone reduction and subsequent UDP-glucuronosyltransferases (UGTs) catalyzed glucuronidation. This study intends to explore the inner link between the cellular glu...
Human UDP-glucuronosyltransferases (UGTs) are pivotal phase II metabolic enzymes facilitating the transfer of glucuronic acid from UDP-glucuronic acid (UDPGA) to various substrates. UGTs are classic type I transmembrane glycoproteins, mainly localized in the endoplasmic reticulum (ER) membrane. This ...
UDP-Glucuronosyltransferases (UGTs) are glycoproteins localized in the endoplasmic reticulum (ER) which catalyze the conjugation of a broad variety of lipo... Anna Radominska-Pandya,PJ Czernik,JM Little,... - 《Drug Metabolism Reviews》 被引量: 958发表: 1999年 UDP-glucuronosyltransferases and...
These UGTs reside on the luminal side of the endoplasmic reticulum and consist of two domains, an N-terminal domain involved in substrate selection and catalysis and a C-terminal domain responsible for binding the glucuronic acid donor, UDP glucuronic acid. The UGT protein is integrated into the...