Therefore, to examine the effects of mutant U2AF1(S34F) on hematopoiesis, we utilized the MSCV-IRES-GFP retroviral system to introduce mutant U2AF1(S34F) or wild type U2AF1(WT), or an empty vector control, into mouse bone marrow cells for in vitro and in vivo studies. Expression of U2...
The functional role of U2AF1 mutations in lung adenocarcinomas (LUADs) remains incompletely understood. Here, we report a significant co-occurrence of U2AF1 S34F mutations with ROS1 translocations in LUADs. To characterize this interaction, we profiled e
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S34F confers a gain of function to the U2af1 protein as indicated by aberrant splicing of U2af1 target genes in cell culture (PMID: 25267526, PMID: 28436936), ectopic expression, and promotion of cell proliferation in culture (PMID: 29991672). Technical Data DNA Change c.101C>T AA ...
We previously identified missense mutations in the U2AF1 splicing factor affecting codons S34 (S34F and S34Y) or Q157 (Q157R and Q157P) in 11% of the patients with de novo myelodysplastic syndrome (MDS). Although the role of U2AF1 as an accessory factor in the U2 snRNP is well ...
Sequence preferences at altered 3′ splice sites associated with U2AF1 S34F/Y mutation.Angela, N. Brooks
S132 BIOLOGICAL CHARACTERIZATION OF THE U2AF1 S34F MUTATION IN THE PATHOGENESIS OF MYELODYSPLASIAdoi:10.1097/01.HS9.0000558748.10139.17Kon, A.Nannya, Y.Kataoka, K.Nakayama, M.Koseki, H.Sanada, M.Makishima, H.Nakagawa, M.M.Ogawa, S.
Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutationdoi:10.1101/2019.12.13.876284Abdalla AkefSteven D. CappellDaniel R. LarsonCold Spring Harbor Laboratory
Decreased CD177 pos neutrophils in myeloid neoplasms is associated with NPM1, RUNX1, TET2, and U2AF1 S34F mutationsKhaled Alayed aHoward J. Meyerson b