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Protein quality control, U-box-containing E3 ubiquitin ligases join the fold. Trends Biochem Sci 27, 368–375. Deb S, Sankaranarayanan S, Wewala G, Widdup E, Samuel MA (2014). The S-domain receptor kinase At- ARK2 and the U-box/ARM-repeat- containing E3 ubiquitin 732 植物学报 51(5...
The U-box is a highly conserved domain recently identified at the C terminus of yeast UFD2, an E4 ubiquitination factor. In yeast, UFD2 is the only U-box-containing protein, but there are two UFD2 homologs and several other proteins containing a U-box domain in humans. Intriguingly, a...
In normal tissues, numerous proteins encoded by proto-oncoproteins are degraded by ubiquitylation enzymes, consisting of F-box/WD-40 repeat-containing protein 7 (Fbw7) and other proteins, thus avoiding tumorigenesis and maintaining homeostasis. In tumor tissues, the downregulation of Fbw7, caused by ...
Map-based cloning of the causal gene allowed us to identify the CERBERUS gene, which encodes a novel protein containing a U-box domain and WD-40 repeats. CERBERUS expression was detected in the roots and nodules, and was enhanced after inoculation of Mesorhizobium loti. Strong expression was ...
Abstract:U— boxdomainwasahighconservedmotifexistingwidelyineukaryotes,especiallyinplants.edo mainofU—box wassimilartothatoftheRING—finger.BothU—boxmotifandRING— fingercouldfunctionasubiquitin—ligaseE3tocatalyzethe targetproteinsubiquitinateddegradation.TheU— boxmotifalsoWasthemainfunctionalfactorofubiquitin...
Protein quality control: U-box-containing E3 ubiquitin ligases join the fold. Trends in biochemical sciences 27, 368–375 (2002). Article CAS PubMed Google Scholar Borden, K. L. & Freemont, P. S. The RING finger domain: a recent example of a sequence—structure family. Current opinion ...
1b) (8), and the sequence similarity extends beyond the C-terminal border of the Prp19p U-box fragment of known tertiary structure (7). This makes structure determination of a typical Arabidopsis U-box domain important. The 632-amino acid residue Arabidopsis AtPUB14 protein (8) was ...
CRISPR/Cas9-mediated double-nucleotide deletion in the OsPUB67 target sequence led to a truncated OsPUB67 protein at the U-box domain. C and D: Phenotypes of OsPUB67 OE3, WT, and M1 plants under control and drought stress conditions. E: The survival rates of the OsPUB67 OE3, WT, ...
U-box域在植物、动物和酵母等真核生物中高度保守,由70多个氨基酸残基构成,最早从酵母UFD2(ubiquitin fusion degradation protein-2)中发现[4]。U-box蛋白参与蛋白泛素化降解,同时也对细胞进行自身功能调控,并对生物胁迫、非生物胁迫、生长发育以及对激素做出响应[5,6,7,8]。GONZALEZ-LAMOTHE等[9]表明CMPG1在...