Protein databases are a type ofbiological databasethat are collections of information about proteins. The information contained in protein databases includes theamino acidsequence, the domain structure, the biological function of the protein, its three-dimensional structure, and its interactions with other...
Databases, ProteinProtein ConformationProteins蛋白质构象蛋白质类Non-covalent residue side-chain interactions occur in many different types of proteins and facilitate many biological functions. Are these differences manifested in the sequence compositions and/or the residue–residue contact preferences of the ...
4. STRING- Known and Predicted Protein-Protein Iinteractions Types:interaction and network、protein Location:Switzerland Citation:9248 z-index:513.78 5. UCSCGenome Browser - University of California,Santa Cruz Genome Browser Types:DNA、基因表达、protein、RNA Location:United States Citation:6429 z-index:...
Example. A few popular databases are GenBank from NCBI (National Center for Biotechnology Information), SwissProt from the Swiss Institute of Bioinformatics and PIR from the Protein Information Resource. Table of Contents Types of Biological Databases 1. Primary databases 2. Secondary databases Importanc...
To aid the assessment and understanding of these variations, population databases such as gnomAD [1], ExAC [2], and ChinaMap [3] have been established. Additionally, genetic disease databases, e.g., ClinVar [4], OMIM [5], and HGMD [6], have also amassed a large amount of information...
W. et al. Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging. Preprint at https://arxiv.org/abs/2107.07953 (2021). Manz, T. et al. Viv: multiscale visualization of high-resolution multiplexed bioimaging data on the web. Preprint at...
Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type atlases of the mouse spinal cord have been published in recent years but have not been integrated together. Here, we generate an atlas of spinal cell types based on single-cell transcriptomic data, unify...
For example, common characteristics that are studied include the histological form (adenocarcinoma vs. squamous cell carcinoma) and mutational state of the protein, C-K-RAS (KRAS) and the epidermal growth factor receptor (EGFR) gene. When considering the whole cancer genome, taking into ...
The database includes RNA and DNA oligonucleotides with two or more bases. It also includes protein-DNA and protein-RNA structures. Applications of nucleotide databases Nucleotide databases are used to identify the gene or the function of a particular nucleotide sequence by comparing an unknown sequen...
Protein interactions mediate a wide spectrum of functions in various cellular contexts. Functional versatility of protein complexes is due to a broad range of structural adaptations that determine their binding affinity, the number of interaction sites,