The phenotype of Langerhans cells, histiocytosis X cells, dermal macrophages and interdigitating reticulum cells were similar (HLA-DR+, OKT 6+/-, Leu3+/-, C3-receptor-, Ig-complex-, R4/23-, MO2-), and differed markedly from those of follicular dendritic cells (HLA-DR-, OKT6-, Leu3...
Acquired Disorders of the Hypothalamo㏄ituitary Axis craniopharyngiomacorticotropinomas ‐ pituitary adenomas in prepubertal childrenhypophysitis ‐ pituitary gland inflammationlangerhans cell histiocytosis (LCH) and ... KSAEC Fellow,Mehul T. Dattani MBBS, DCH, FRCPCH, FRCP, MD Professor - Wiley‐Blackwell...
Single-cell RNA sequencing studies have suggested that total mRNA content correlates with tumor phenotypes. Technical and analytical challenges, however, have so far impeded at-scale pan-cancer examination of total mRNA content. Here we present a method
We analyzed multiple tumor types including melanoma, colorectal carcinoma, papillary thyroid cancer, hairy cell leukemia, and Langerhans cell histiocytosis using both DNA-based sequencing and the BRAF Y600E mutation-specific antibody. Our results show a high degree of concordance between the 2 methods...
LCH, Langerhans cell histiocytosisMatrix metalloproteinases (MMPs) are endopeptidases with the potential to cleave extracellular matrix, support tissue renewal and regulate cell migration. Functional activities of MMPs are regulated by tissue inhibitors of MMPs (TIMPs) and disruption of the MMP-TIMP ...