Bone marrow, soft, gelatinous tissue that fills the cavities of the bones. Bone marrow is either red or yellow, depending upon the preponderance of hematopoietic (red) or fatty (yellow) tissue. In humans the red bone marrow forms all of the blood cells w
It is now accepted that HCV is a cause of liver diseases and a number of other lymphoproliferative disorders such as mixed cryoglobulinemia (MC) [7–10] and Non-Hodgkin's lymphoma (NHL) [11–14]. Other lymphoproliferative disorders may also be associated with HCV infection [15]. Although th...
Expression of eigengenes in the MILE dataset. Each row corresponds to a sample. Modules (columns) are clustered based on the similarity of expression in the MILE dataset. The majority of eigengenes show a different pattern of expression in the two diseases. The green strip at the top shows ...
heritability enrichment of immune cell-type programs (columns) are shown for blood cell traits (rows,d) or immune-related diseases (rows,e).f, Examples of inter- and intracell-type cellular process programs. UMAP of PBMCs (as ina) are colored by each program weight (color bar) from NMF....
Hepatitis C Virus (HCV) is a single stranded RNA virus which produces negative strand RNA as a replicative intermediate. We analyzed 75 RT-PCR studies that tested for negative strand HCV RNA in liver and other human tissues. 85% of the studies that inves
ETIOLOGY of diseasesLOCUS (Genetics)Clonal hematopoiesis (CH)鈥攁ge-related expansion of mutated hematopoietic clones鈥攃an differ in frequency and cellular fitness by CH type (e.g., mutations in driver genes (CHIP), gains/losses and copy-neutral loss of chromosomal segments (mCAs), and loss ...
neural and hematopoietic stem cellsNeural and hematopoietic stem cells have tremendous potential in the development of therapies for certain diseases, such as diabetes and Parkinson disease. Neural stem cells occur in the spinal cord and in specific regions of the brain, and hematopoietic stem cells ...
of receptor ectodomains. Specific activities of cytokines have been the basis for current concepts of therapeutical intervention, in particular of the treatment of hematopoietic malfunctions and tumor therapy. Applications involve the support of chemo- and radiotherapy, bone marrow transplantation, and ge...
White blood cells start out in the bone marrow in a process called hematopoiesis. All blood cells come from a commonhematopoieticstem cell (HSC). These stem cells specialize—or differentiate—in different stages. The HSC cell first separates into one of two types of stem cells: ...
4). Altogether, the observation of contributions from many non-hematopoietic cell types underscores the ability to simultaneously non-invasively resolve contributions to cfRNA from disparate cell types across the body. Some cell types likely present in the plasma cell-free transcriptome were missing in...