Left side, top: the minimal common denominator of HD leukemia is always a bi-parental derived tetrasomy 21, irrespective of whether it arises in a constitutional normal or trisomic individual. Left side, middle: the duplication of either the wild-type or variant allele of pharmacologically relevant...
Congenital defects of the erythrocyte membrane are common in northern Europe and all over the world. The resulting diseases, for example, hereditary spherocytosis (HS), are often underdiagnosed, partly due to their sometimes mild and asymptomatic courses. In addition to a broad clinical spectrum, th...
Skysona carries a Boxed Warning for hematologic malignancies, including life-threatening cases of myelodysplastic syndrome. The most common adverse reactions (≥ 20%) include: mucositis (mouth sores, inflammation), nausea, vomiting, febrile neutropenia (fever with low white blood cell count), and ...
taking medication for treatment of migraine attacks on 10 or more days per month in any of the previous 3 months; clinically significant hematologic, endocrine, cardiovascular, cerebrovascular, pulmonary, renal, hepatic, gastrointestinal, or neurologic disease; and a history of 15 or more headache da...
Human immunodeficiency virus (HIV) infection is a serious problem throughout the world. Diarrhea is one of the most common gastrointestinal complicati.. Human immunodeficiency virus (HIV) infection is a serious problem throughout the world. Diarrhea is one of the most common gastrointestinal ...
It is common for patients newly diagnosed with APL to present elevated d-dimer levels, fibrin split products, prolonged PT, and partial thromboplastin time and hypo fibrinogenemia.14 These unusual indicators are related to the clinical manifestations of a high risk of bleeding and throm- ...
Cancer is defined by the WHO (World Health Organization) as a group of diseases caused by abnormal, uncontrolled cell growth, which can be located in almost any organ or tissue of the body.1 The pr...
抗精神病药物治疗早期最常见的不良反应(Antipsychotic treatment was the most common adverse event in the early stage) 5.3.3.1.1 over sedation The most common adverse effects of antipsychotic treatment are sedation, weakness, and dizziness, with a prevalence of more than 10%. Chlorpromazine and chlorin...
In this chapter, we will highlight the most recent and clinically relevant developments in the arena of gene-modified T-cell-based therapies and hematopoietic stem cellular gene therapy specifically focusing on hematologic disorders. We will conclude the chapter by summarizing the apparent challenges ...
limitation. Persistence or reappearance of PCR positivity for PML/RARA in patients with morphological remission was correlated with impending hematologic relapse [84]. This allowed the identification of patients requiring treatment intensification [86,87] and permitted the kinetics of response and disease ...