With the increase in DNA and protein sequencedatabases, there is a growing need for more faster and efficient methods to analyze this large amount of data. One of the most commonly used bioinformatics tools today to study DNA and protein sequences is called BLAST. BLAST stands for Basic Local...
Nucleotide databases are used to identify the gene or the function of a particular nucleotide sequence by comparing an unknown sequence with the known sequences in the database. Nucleotide databases can be used to study and examine gene expression by using the sequence information stored in the da...
Single cell technologies are rapidly generating large amounts of data that enables us to understand biological systems at single-cell resolution. However, joint analysis of datasets generated by independent labs remains challenging due to a lack of consi
Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics 18, S96–S104 (2002). Article PubMed Google Scholar Stekhoven, D. J. & Buhlmann, P. MissForest-non-parametric missing value imputation for mixed-type data. ...
Bioinformatics 27, 2288–2295 (2011). Article CAS PubMed PubMed Central Google Scholar Géron, A., Werner, J., Wattiez, R., Lebaron, P. & Mattallana-Surget, S. Deciphering the functioning of microbial communities: shedding light on the critical steps in metaproteomics. Front. Microbiol....
have been established. Additionally, genetic disease databases, e.g., ClinVar [4], OMIM [5], and HGMD [6], have also amassed a large amount of information on known pathogenic or benign genetic variations. These databases have been widely used as references in the genetic diagnosis of Mendel...
Bioinformatics Automation in Bioinformatics Introduction Recent advancements in single-cell RNA sequencing (scRNA-seq) have furthered the understanding of heterogeneous cell compositions in complex tissues through the characterization of different cell types based on gene expression levels, thus facilitating our...
Multiplexed fluorescence in situ hybridization techniques have enabled cell-type identification, linking transcriptional heterogeneity with spatial heterogeneity of cells. However, inaccurate cell segmentation reduces the efficacy of cell-type identifica
Biological Databases- Types and Importance. A biological database is a large, organized body of persistent data, usually associated with computerized software designed to update, query, and retrieve components of the data stored within the system.
Primary and secondary databases | Bioinformatics for the terrified (ebi.ac.uk) Tateno, Y., Imanishi, T., Miyazaki, S., Fukami-Kobayashi, K., Saitou, N., Sugawara, H., & Gojobori, T. (2002). DNA Data Bank of Japan (DDBJ) for genome scale research in life science. Nucleic Acids Re...