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But further longitudinal studies are warranted to determine whether epicardial fat could participate in the appearance or in the progression of DR and longitudinal follow-up of Angiosafe-DT2 at 3 years will probably help to answer this still open question. Our study has several limitations. First,...
progression of renal disease, and all-cause mortality. These new data are leading to a paradigm shift in the current management of T2D, with international guidelines now prioritising SGLT2 inhibitors and/or GLP-1 RAs in certain patient populations. However, clinicians are faced with a large volum...
Download: Download high-res image (2MB) Download: Download full-size image Figure 9. Mechanisms driving the development of atherosclerotic lesions in patients with type 2 diabetes (A) and effects of GLP-1 RAs on the progression of atherogenesis and the development of its complications (B). See...
Cancer-associated fibroblasts (CAFs) constitute a prominent component of the tumor microenvironment and play critical roles in cancer progression and drug resistance. Although recent studies indicate CAFs may consist of several CAF subtypes, the breadth of CAF heterogeneity and functional roles of CAF su...
Chronic inflammation represents a key pathogeneric event in the progression of lung disease in cystic fibrosis (CF). To identify novel mechanisms of the in... RW Farndale,JJ Sixma,MJ Barnes,... - 《Journal of Thrombosis & Haemostasis》 被引量: 401发表: 2004年 Critical role of the CD40 ...
Lifestyle interventions have been recognized by experts and scholars as an effective means for the treatment of T2D and dietary changes can effectively improve insulin sensitivity, prevent the progression of the disease and delay the occurrence of complications [6, 7]. Current studies have shown ...
In conclusion, lixisenatide reduced progression of UACR specifically in macroalbuminuric patients, but did not affect eGFR.34 In the LEADER trial, the composite kidney outcome was new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine levels, ESKD, or death due to kidney ...
Aortic dissection (AD) is one of the fatal and complex conditions. Since there is a lack of a specific treatment guideline for type-B AD, a better understanding of patient-specific hemodynamics and therapy outcomes can potentially control the progression
Luan J, Shattuck-Brandt R, Haghnegahdar H, Owen JD, Strieter R, Burdick M, Nirodi C, Beauchamp D, Johnson KN, Richmond A: Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression. J Leukoc Biol. 1997, 62 (5): 588-59...