Our research has discovered that extracellular vesicles derived from mesenchymal stem cells found in bone marrow, which contain TGFB1, possess the potential to regulate the progression of osteoarthritis. In contrast to other diseases, such as heart disease and diabetes, the extracellular vesicles ...
The drop in lymphocytes during inflammation can trigger an increase in the production of oxidative stress, proinflammatory cytokines and cell apoptosis [50], potentially worsening inflammation and playing a role in disease progression. As people age, they often experience higher levels of inflammatory ...
Single-cell analysis of fate-mapped macrophages reveals heterogeneity, including stem-like properties, during atherosclerosis progression and regression. JCI Insight. 2019. https://doi.org/10.1172/jci.insight.124574. Article PubMed PubMed Central Google Scholar Dobnikar L, Taylor AL, Chappell J, ...
ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis. Oncogenesis. 2020;9(4):42. Article PubMed PubMed Central CAS Google Scholar Lencioni R, de Baere T, Soulen M, Rilling W, Geschwind J. Lipiodol transarterial chemoembolization for ...
(2023). Lipoprotein(a) and calcific aortic valve disease initiation and progression: a systematic review and meta-analysis. Cardiovasc Res, 119(8), 1641–1655. https://doi.org/10.1093/cvr/cvad062. Passmore M, Nataatmadja M, Fung YL, Pearse B, Gabriel S, Tesar P, Fraser JF. Osteopontin...
This dysregulation may contribute to disease progression, symptom burden, and potentially influence therapeutic responses. Additionally, consistent with our results, other studies have shown that EPO stimulation of JAK2-V617F cells can result in a significant increase in Ier2 and SOCS expression [83,...
ApoC-III is an important CVD risk factor also in individuals with type 1 diabetes [20] and we recently showed that apoC-III concentrations are elevated in individuals with DKD and predict future DKD progression [82]. However, with a low number of the RBM47...
type cells (Fig.2D). This increase was not a consequence of transcriptional upregulation, since Cdc20Slp1mRNA expression levels were similar betweenpmk1Δ cells and the wild type (Fig.2E). Next, we analyzed the effect of Pmk1 activity on Cdc20Slp1protein levels during mitotic progression. ...
Hultström M, Lipcsey M, Wallin E, Larsson IM, Larsson A, Frithiof R (2021) Severe acute kidney injury associated with progression of chronic kidney disease after critical COVID-19. Crit Care 25:37 Article PubMed PubMed Central Google Scholar Luther T, Bülow-Anderberg S, Larsson A, ...
[10]. MiRNAs also regulate the expression of target genes by binding to mRNAs, playing a crucial role in several processes, such as cellular differentiation, development, and disease progression. CircRNAs play a unique role in regulating gene expression and cellular processes due to their ...