The p53 gene has been found to be mutated in many different kinds of human cancers. In a previous study, expression of exogenous wild-type p53 in human osteosarcoma cells by retrovirus-mediated gene transfer resulted in marked enlargement of cell size, reduced growth rate in culture and loss ...
Many human papillomavirus (HPV)-positive high-grade lesions and cancers of the uterine cervix harbor integrated HPV genomes expressing the E6 and E7 oncogenes from chimeric virus-cell mRNAs, but less is known about HPV integration in head and neck cancer (HNC). Here we compared viral DNA statu...
HPV causes virtually all cervical cancer and associated cancers (i.e., oropharyngeal, vulvar, vaginal, penile, and anal cancers)11. Cervical cancer is among the most common cancers causing death for women in developing countries12. In 2018, there were 570,000 new cases of cervical cancer, ...
HPV 16 and 18 are the most common types of HPVs found in ICC. Whereas the proportion of HPV 16 and 18-associated cancers appears rather constant worldwide, the relative importance of the other carcinogenic HPV types differs slightly by geographical region (de Sanjose et al, 2010; Li et ...
Oncolysis of human ovarian cancers by echovirus type 1. Int J Cancer 2005; 115: 320-328.Shafren DR, Sylvester D, Johansson ES, Campbell IG, Barry RD. Oncolysis of human ovarian cancers by echovirus type 1. Int J Cancer 2005;115(2):320-8....
discovered that an artificially-derived mutant of SWAP-70 can transform mouse embryo fibroblasts, we searched for naturally-occurring mutations in the SWAP-70 gene, finding listings for several on the Web at www.sanger.ac.uk/genetics/CGP/cosmic/, including three mutations found in ovarian cancers...
Breast cancer is the leading cause of both incidence and mortality in women population. For this reason, much research effort has been devoted to develop Computer-Aided Detection (CAD) systems for early detection of the breast cancers on mammograms. In this paper, we propose a new and novel ...
The crucial role of vascular endothelial growth Factor A (VEGFA) in healthy rat livers undergoing partial hepatectomy under vascular occlusion (PH + I/R) has been demonstrated. This study evaluates whether this observation can be extrapolated to th
Previous research has suggested that certain cancers that express the CD24 protein are also vulnerable to the Zika virus, opening the door for Zika virus to be used as a treatment. In this study, Westmoreland and first author Joseph Mazar, Ph.D., Research Scientist at Nemours Children's, ex...
Mutant-type p53 (mt p53) is largely accumulated in cancer cells due to its increased stability. To elucidate the mechanism of mt p53 stabilization, we analysed the turnover of p53 mutated at codon 248 whose alteration is most frequently found in human cancers. Proteasome inhibition induced the ...