To evaluate the effect of diabetes, we compared the diagnostic accuracy of the fibrosis(FIB index, the NAFLD fibrosis score (NFS), the aspartate aminotransferase to platelet ratio index (APRI), and type IV collagen 7S (COL4) in patients with NAFLD with and without diabetes. The areas under ...
To evaluate liver status, type IV collagen 7s, procollagen type III peptide, and hyaluronic acid levels were measured. The mean age of the 62 patients was 14.0±7.2years. The mean central venous pressure was 6.8±3.5mmHg and mean right ventricular end-diastolic pressure was 7.9±3.5mmHg. The...
中文名称 :Ⅳ型胶原(collagen type Ⅳ,CIV)及其分解片段(7S片段和NC1片段)检测试验 英文名称 : 别名: ICD 号:c16.9 原理 CIV分布于肝窦内皮细胞下,是肝基底膜的主要成分。7S片段是CIV氨基末端的四聚体,NC1片段是CIV羧基末端的二聚体。血清CIV、7S及NC1均主要是从肝基底膜降解而来,为反映胶原降解的指标,不断...
Further analysis revealed that the time taken for the recovery of ChildPugh scores and serum total bilirubin and albumin levels was significantly shorter in patients with type IV collagen 7 S ≤ 6 ng/mL than in those with type IV collagen 7 S > 6 ng/mL. In additional analyses, similar ...
Figure 2.Structure of type IV collagen. (a) Each of the six individualα-chains contains an N-terminal 7S domain, a central collagenous domain with multiple interruptions, and a C-terminal noncollagenous domain (NC1). (b) Threeα-chains assemble in a defined fashion to form the three type...
THE USE OF ISOLATED DOMAINS OF TYPE IV COLLAGEN TO MODIFY CELL AND TISSUE INTERACTIONSThe instant invention demonstrates that the 7S domain of type IV collagen disrupts cell aggregation and tissue development. Structural changes in mesoglea, inhibition of cell proliferation, and changes in cell ...
The most well-studied mutations in type IV collagen cause Alport syndrome, a chronic kidney disease. Several biomarkers of type IV collagen have been developed, both formation and degradation fragments as well as whole domains such as 7S, documenting the importance of type IV collagen turnover in...
胶原蛋白IV型 来源于人类细胞培养基 Collagen Type IV from human cell culture 基本信息 EC number【EC 号】 232-697-4 MDL number MFCD00130825 NACRES NA.75 General description【一般描述】 COL4A1(IV型胶原蛋白α 1链)属于胶原蛋白家族。它具有N末端7S结构域、C末端球状结构域(NC1),以及包含Gly-X-Y重...
collagens found in the basement membrane, and are usually used as a marker of the basement membrane dynamic stability. The type IV collagen fiber exists as a trimeric complex comprised of two molecules of COL4A1 and one molecule of COL4A2. The N-terminal 7S domains of the protein function ...
A simple clinical scoring system using ferritin, fasting insulin, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease Background Liver histology is the gold standard for the diagnosis of nonalcoholic steatohepatitis ( NASH ). Noninvasive, simple, reproducible, ...