To evaluate the effect of diabetes, we compared the diagnostic accuracy of the fibrosis(FIB index, the NAFLD fibrosis score (NFS), the aspartate aminotransferase to platelet ratio index (APRI), and type IV collagen 7S (COL4) in patients with NAFLD with and without diabetes. The areas under ...
To evaluate liver status, type IV collagen 7s, procollagen type III peptide, and hyaluronic acid levels were measured. The mean age of the 62 patients was 14.0±7.2years. The mean central venous pressure was 6.8±3.5mmHg and mean right ventricular end-diastolic pressure was 7.9±3.5mmHg. The...
中文名称 :Ⅳ型胶原(collagen type Ⅳ,CIV)及其分解片段(7S片段和NC1片段)检测试验 英文名称 : 别名: ICD 号:c16.9 原理 CIV分布于肝窦内皮细胞下,是肝基底膜的主要成分。7S片段是CIV氨基末端的四聚体,NC1片段是CIV羧基末端的二聚体。血清CIV、7S及NC1均主要是从肝基底膜降解而来,为反映胶原降解的指标,不断...
of < 2 mg/dL and > 2.8 g/dL, respectively, and the time taken for Child-Pugh score to return to ChildPugh class A.RESULTS Preoperative type IV collagen 7 S was identified as a significant independent factor associated with both PHLF and postoperative long-term recovery of liver function....
Domain: Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.Post-...
Several biomarkers of type IV collagen have been developed, both formation and degradation fragments as well as whole domains such as 7S, documenting the importance of type IV collagen turnover in most, if not all, connective tissue diseases. 展开 ...
1, 2, 3 Type IV collagen is the predominant component of the basement membrane,4 and serves as a scaffold for the adherence and migration of neutrophils.3, 5, 6 It is thought that neutrophils have adhesion molecules for type IV collagen, and some molecules have been reported.6, 7 The ...
Type IV collagens are the major structural component of allbasement membranesin animal phyla. Individualtype IV collagenmolecules are composed of three long triple-helical collagen α-chains (Figure 4.2). Each α-chain contains a short 7S domain at the N-terminal, followed by an approximately 140...
The FIB-4 index was measured as a marker of liver fibrosis, and multiple linear regression analysis was performed to examine its association with serum free testosterone concentration. In addition, the 7S domain of type IV collagen (IV-7S) was examined in 140 of the 248 patients. The mean ...
7 amino acids were chosen as a target site from the C-terminal part of type XXVIII collagen (QETCIQG). The peptides used for immunization included 1) immunogenic peptide (KLH-CGG-QETCIQG), 2) coating peptide/screening peptide (biotin-QETCIQG), 3) standard peptide (QETCIQG) and 4)...