导读 近日,南方科技大学李闯创团队在美国化学会《Accounts of Chemical Research》(《化学研究评述》)在线发表了题为“Total Synthesis of Natural Products with Bridged Bicyclo[m.n.1] Ring Systems via Type II [5+2] Cycloaddition”的特邀综述性文章。该综述性论文系统总结了李闯创团队近5年来,利用本课题组...
703.),以“Total Synthesis of Natural Products with Bridged Bicyclo[m.n.1] Ring Systems via Type II [5+2] Cycloaddition”为题,首次系统总结了课题组利用Type II [5+2] 反应,完成多个复杂活性天然产物全合成的成功案例(图1)。
1)Total Synthesis of Natural Products with Bridged Ring Systems via Type II [5+2] Cycloaddition 2)Total Synthesis of Natural Products Containing a Bridgehead Double Bond 3)Asymmetric Total Synthesis of (−)-Vinigrol 4)Asymmetric Total Synthesis of Cerorubenic Acid-III 5)Asymmetric Total Synthesi...
Type II [5+2] Paclitaxel Cyclocitrinol Vinigrol Bufospirostenin A Type II [5+2] cycloaddition reaction One-step direct synthesis of 7-membered bridged ring system. High substrate utility, generating high tension bridgehead double bonds, multiple chiral centers (quaternary carbon centers) ★...
type II [5+2] cycloadditionMain observation and conclusion The asymmetric total synthesis of an unusual C25 steroid containing a unique bicyclo[4.4.1]undecene A/B ring system, resulting in the synthesis of cyclocitrinol (1) and its isomer Δ8,14ヽyclocitrinol (38), are reported. Initial ...
近日,中国海洋大学医药学院分子合成中心的徐涛教授团队关于Type II [4+4]型高张力桥环构建的研究成果,以“Regioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition”为题,发表于Nature系列学术期刊《Nature Communications》(《自然·通讯...
近日，南科大李闯创团队在国际权威综述学术期刊《Chemical Society Reviews》（IF：42.8），在线发表了题为“Synthetic Applications of Type II Intramolecular Cycloadditions”的特邀综述性文章，首次系统总结了近四十年来，Type II 环加成反应在高效构建各种桥环体系及其在天然产物全合成中的应用。图1. TypeII 环加成...
cycloaddition reactionsVinyl ketenes, generated from the dienoic acids (I), (V), (VIII), and (XI) via their acid chlorides, undergo intramolecular cycloaddition to produce the fused cyclobutanones (II), (VI), and (VII), (IX) and (X) or (XII) and (XIII) as shown in the reaction ...
近日,南方科技大学李闯创教授课题组,在国际知名期刊《Nature Communications》上以“Facile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions”为题,首次报道了铑催化的Type ...
Things are too long away now for introducing any change, but one should remember that using Norrish name here is a mistake, while it would be appropriate to add the name of Ciamician for a different name reaction, the 2 + 2 cycloaddition of alkenes and conjugated carbonyls. In 1968, such...