Cell membrane spanning proteins contain a luminal/extracellular domain, a transmembrane region and a cytosolic domain. In a type I transmembrane protein the N‐terminus is the extracellular/luminal part of the protein, whereas the C‐terminus comprises the cytosolic region of the membrane protein. ...
Cell membrane spanning proteins contain a luminal/extracellular domain, a transmembrane region and a cytosolic domain. In a type I transmembrane protein the N‐terminus is the extracellular/luminal part of the protein, whereas the C‐terminus comprises the cytosolic region of the membrane protein. Tu...
Dosztányi, I. Simon PDB_TM: selection and membrane localization of transmembrane proteins in the protein data bank Nucleic Acids Res, 33 (2005), pp. D275-D278, 10.1093/nar/gki002 Google Scholar [38] D. Kozma, I. Simon, G.E. Tusnády PDBTM: Protein Data Bank of transmembrane ...
et al. Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nature Commun. 4, 1418 (2013). This is a follow-up study to reference 38, showing that IFITM3 variants that contribute to the severity of influenza virus ...
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 73, 1197–1206 (1993). Article CAS PubMed Google Scholar Harding, H. P., Zhang, Y. & Ron, D. Protein translation and folding are coupled by an endoplasmic-reticulum-...
The distribution of amino acids in the transmembrane segments and flanking regions of 115 human type I single span (amino terminus extracellular and carboxyl terminus cytosolic) plasma membrane proteins was found to be non-random. In this sample, Ile was preferentially localized to the amino-terminal...
跨膜结构域(Transmembrane domain):N-末端显示跨膜结构域(transmembrane domain,TMD) 对于VirD4型T4CP,TMD对于体内接合是必需的。该结构域参与T4CP和VirB10蛋白之间的相互作用,这对于T4SS的激活至关重要。此外,TMD对于蛋白质寡聚化至关重要,因为它包含此类过程的关键残基。TMD由α螺旋形成,并包含T4SS相互作用和T4CP...
1). Thus, the mature GPI-anchored proteins have no transmembrane or intracellular domains. Attachment of the GPI moiety after translation of MT4-MMP and MT6-MMP seems to occur efficiently as around 50% of cellular MT-MMPs contain the GPI moiety under an over expressing system [103], [147]...
背景说明:NKG2-A/NKG2-B Type II Integral Membrane Protein contains 1 C-type lectin domain and belongs to the killer cell lectin-like receptor family. The killer cell lectin-like receptor family is a group of transmembrane proteins preferentially expressed in NK cells. Members of this proteins is...
The purity of intact lysosomes was confirmed by blotting for LAMP2, a lysosomal transmembrane protein, cathepsin C, a lysosomal lumen protein, and β-actin, which is excluded from the lysosome (Fig. 4b; Supplementary Table 5). Proteomic analysis of the lysosomal samples revealed enrichment of ...