A transmembrane protein that exposes its carboxyl terminus into the cytosol. Endoplasmic Reticulum StressSpringerVerlag Berlin HeidelbergSpringer Berlin HeidelbergTRANSMEMBRANE PROTEIN 43; TMEM43. 2011; Available from: http://www.ncbi.nlm.nih.gov/omim/612048....
Cell membrane spanning proteins contain a luminal/extracellular domain, a transmembrane region and a cytosolic domain. In a type I transmembrane protein the N‐terminus is the extracellular/luminal part of the protein, whereas the C‐terminus comprises the cytosolic region of the membrane protein. Tu...
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat. Genet. 20, 143–148 (1998). Article CAS PubMed Google Scholar Valero, R., Bannwarth, S., Roman, S., Paquis-Flucklinger, V. & Vialettes, B. Autosomal ...
背景说明:Interleukin 1 receptor, type I (IL-1R1) is an interleukin receptor that belongs to the interleukin-1 receptor family. IL-1R1 is an 80 kDa transmembrane protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. This gene along with IL1R2, IL1RL2, and...
The positional preferences of these particular amino acids within the transmembrane segment and flanking regions suggests that, in addition to lipid-protein interactions, these residues may participate in specific protein-protein interactions. A consensus sequence motif for type I membrane proteins is ...
The purity of intact lysosomes was confirmed by blotting for LAMP2, a lysosomal transmembrane protein, cathepsin C, a lysosomal lumen protein, and β-actin, which is excluded from the lysosome (Fig. 4b; Supplementary Table 5). Proteomic analysis of the lysosomal samples revealed enrichment of ...
Periplasmic part of each protomer of TolC protein consists of two internal repeats of α-hairpin forming a very long α-barrel and then all three protomers form a 12 β-strands in the transmembrane part, and thereby the exit route to complete the secretion (Koronakis et al., 1997; Jo ...
Alg2 is an α-1,3-mannosyltransferase forming a type I transmembrane protein on the ER, with its active site being cytosolically oriented (25). To date, no information has been reported to link Alg2 to cell differentiation. We confirmed the microarray results by qRT-PCR (Fig. 3B) or ...
et al. Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nature Commun. 4, 1418 (2013). This is a follow-up study to reference 38, showing that IFITM3 variants that contribute to the severity of influenza virus ...
RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells Development of probes specific for human β-cells could aid in delivery of therapeutics and monitoring β-cells mass during diabetes progr...