MAST cell diseaseATOPYType 2 inflammatory diseases are characterized by the dysregulation of the T helper (Th) 2 pathway, the prototype being atopic dermatitis (AD). The common inflammatory pathways, genetic risk factors, epidermal barrier dysfunction, parental atopy, and environmental factors are all...
Learn More Prurigo Nodularis (PN) TYPE 2 INFLAMMATION may impact both itch and lesions in PN12-15 Learn More Eosinophilic Esophagitis (EoE) ~75% of patients with eosinophilic esophagitis have at least one coexisting Type 2 inflammatory disease1,16 Learn More EXPLORE...
Eosinophilic cellulitis seems to be a type 2 inflammatory disease, with preferential activation of the Janus kinase (JAK)1/JAK2-signal transducer and activator of transcription (STAT)5 pathways, according to research published online June 21 inJAMA Dermatology. Johanna Morot, from the Université Clau...
Bullous pemphigoid (BP) is a type 2 inflammation- and immunity-driven skin disease, yet a comprehensive understanding of the immune landscape, particularly immune-stromal crosstalk in BP, remains elusive. Herein, using single-cell RNA sequencing (scRNA-s
Inflammatory bowel disease (IBD) is a type of chronic intestinal inflammation mediated by abnormal immunity. Ulcerative colitis (UC) and Crohn's disease (CD) are the two main forms of IBD, which currently affect about 0.3% of the world's population, or more than 20 million people1. The in...
“Many gastroenterologists have little experience with type 2 inflammatory diseases, and the ADVENT medical education program can help them gain more insights into this phenomenon.” Gastroenterologist Prof. Arjan Bredenoord Meet our experts Dermatology ...
Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β-cells and/or peripheral insulin resistance, resulting in impaired glucose and lipid metabolism. Genetic, metabolic, multiple lifestyl...
E. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 11, 98–107 (2011). Article PubMed CAS Google Scholar Kolb, H. & Mandrup-Poulsen, T. An immune origin of type 2 diabetes? Diabetologia 48, 1038–1050 (2005). Article PubMed CAS Google Scholar Donath, M. Y., ...
Low-grade inflammation is a common feature in subjects with type 2 diabetes (T2D). Heart disease, the metabolic syndrome and T2D all have in common the increased concentration of circulatory cytokines as a result of inflammation. Inflammatory cytokines are produced by different cell types and secret...
Patients with asthma who had a mean BEC ≥150 cells/μL before COVID-19 were 54% (95% CI: 2-79) less likely to be admitted, whereas those with comorbid heart failure, chronic kidney disease, or chronic obstructive pulmonary disease (COPD), but not allergic comorbidities, were more ...