Type 2 inflammatory diseases are characterized by the dysregulation of the T helper (Th) 2 pathway, the prototype being atopic dermatitis (AD). The common inflammatory pathways, genetic risk factors, epidermal barrier dysfunction, parental atopy, and environmental factors are all associated with the ...
Overall, fibroblast-derived PLA2G2A drove secretion of myeloid-derived CCL17, which further induced the IL-13-mediated immunity in the development of BP and type 2 inflammatory diseases, suggesting that PLA2G2A and CCL17 serve as promising therapeutic targets in BP. Both PLA2G2A and CCL17 prom...
The translational revolution and use of biologics in patients with inflammatory skin diseases. J Allergy Clin Immunol. 2015;135(2):324-336. 21. Hammad H, Lambrecht BN. Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat Rev Immunol. 2008;8(3):193-204....
Eosinophilic cellulitis seems to be a type 2 inflammatory disease, with preferential activation of the Janus kinase (JAK)1/JAK2-signal transducer and activator of transcription (STAT)5 pathways, according to research published online June 21 inJAMA Dermatology. Johanna Morot, from the Université Clau...
Similar with other chronic inflammatory diseases, IBD usually develops early in life and is accompanied by a host of sequelae and comorbidities, including rheumatic diseases, iron-deficiency anemia, and cancer, and is therefore a major contributor to the global burden of disease7. In addition, IBD...
“Many gastroenterologists have little experience with type 2 inflammatory diseases, and the ADVENT medical education program can help them gain more insights into this phenomenon.” Gastroenterologist Prof. Arjan Bredenoord Meet our experts Dermatology ...
Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases (NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β-cells and/or peripheral insulin resistance, resulting in impaired glucose and lipid metabolism. Genetic, metabolic, multiple lifestyl...
Tuberculosis and Type 2 Diabetes Mellitus: An Inflammatory Danger Signal in the Time of Coronavirus Disease 2019 COMMENT RJ Wilkinson - 《Clinical Infectious Diseases》 被引量: 0发表: 2021年 Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors The role...
Moreover, such patients had a significantly greater BEC before admission amounting to the mean difference of 74 cells/μL, whereas there were no differences in inflammatory markers. There was no such relationship between lymphocyte or platelet counts and mortality in admitted patients. Larger cohorts...
Diabetes Type II Reference work entry First Online:01 January 2017 pp 454–457 Cite this reference work entry Compendium of Inflammatory Diseases Anil Kumar Ramaswamy 82Accesses Synonyms Adult-onset diabetes mellitus; Adult-onset diabetes; Ketoacidosis-resistant diabetes mellitus; Ketoacidosis-resistant ...