In this sense, the serotonergic system stands out for its relevance in the diabetic pathophysiology, since: (i) 5-HT concentrations are altered in diabetes7,8; (ii) 5-HT inhibits the peripheral sympathetic neurotransmission in type 1 diabetic rats9,10; (iii) it has been described an cior...
TTTTA repeats region (right). Individuals with larger TTTCA repeat region have an earlier age at seizure onset. On the contrary, neither the size of 5ʹ-TTTTA or 5ʹ + 3ʹ-TTTTA repeats correlate with the age at epilepsy onset. Individuals included in the graph are 1-IV-6, ...
Advances in our understanding of the pathophysiology of Type 1 diabetes: Lessons from the NOD mouse. Clin. Sci. 2014, 126, 1–18. [CrossRef] 54. Wållberg, M.; Cooke, A. Immune mechanisms in type 1 diabetes. Trends Immunol. 2013, 34, 583–591. [CrossRef] [PubMed] 55. Chen, S...
International Journal of Molecular Sciences Article Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in Streptococcus pneumoniae Miriam García-López 1 , Pablo Hernández 2, Diego Megias 3, María-José Ferrándiz 1,* and Adela G. de la ...
Pathophysiology of type 1 and type 2 diabetes mellitus: A 90-year perspective. Postgrad. Med. J. 2016, 92, 63–69. [CrossRef] [PubMed] 13. Kahn, S.E.; Cooper, M.E.; Del Prato, S. Pathophysiology and treatment of type 2 diabetes: Perspectives on the past, present, and future....
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As an essential component in cell membranes [48], and a mediator of cell proliferation and inflammatory pathways [41,49], there are multiple ways cholesterol needs can be exploited to target PCa pathophysiology. Fortunately, this has led to investigations into potential therapies that either ...
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Multi-Organ Protective Effects of Curcumin Nanoparticles on Drug-Induced Acute Myocardial Infarction in Rats with Type 1 Diabetes Mellitus. Appl. Sci. 2021, 11, 5497. https://doi.org/ 10.3390/app11125497 1 Department of Pathophysiology, Iuliu Ha¸tieganu University of Medicine and Pharmacy Cluj...
2. Vitamin D Synthesis and Metabolism The pathophysiology of the insulin-resistant state and islet dysfunction remains enigmatic. Currently, patients with insulin resistance and islet dysfunction are treated with insulin sensitizers and secretagogues, which work mainly by improving glucose disposal via ...