Type 1 narcolepsy: a CD8(+) T cell-mediated disease? Ann N Y Acad Sci. 2015; 1351 :80–88. doi: 10.1111/nyas.12793. [ Cross Ref ]Degn, M. & Kornum, B. R. Type 1 narcolepsy: a CD8 + T cell-mediated disease? Ann. N. Y. Acad. Sci. 1351, 80-88 (2015)....
Narcolepsy type 1 (NT1) is a rare sleep disorder caused by the very specific loss of hypothalamic hypocretin (Hcrt)/orexin neurons. The exact underlying process leading to this destruction is yet unknown, but indirect evidence strongly supports an autoimmune origin. The association with immune-...
Narcolepsy type 1 (NT1) is a chronic neurological disorder characterized by symptoms such as excessive daytime sleepiness, sudden sleep episodes, disrupted nocturnal sleep, cataplexy, sleep paralysis, and hypnagogic hallucinations, which significantly impact the overall well-being and quality of life of...
To assess whether brain histamine (HA) is also involved, we quantified the cerebrospinal fluid (CSF) levels of HA and tele‐methylhistamine (t‐MeHA), the direct metabolite of HA between children with orexin‐deficient narcolepsy type 1 (NT1) and controls.Patricia Franco...
Narcolepsy type 1 is a chronic sleep disorder caused by a deficiency of the orexin (hypocretin) neuropeptides. In addition to sleep regulation, orexin is important for motivated control processes. Weight gain and obesity are common in narcolepsy. However, the neurocognitive processes associated with ...
Narcolepsy type 1 (NT1) has been shown to result from a selective loss of hypothalamic hypocretin-secreting neurons with patients typically showing low CSF-hypocretin levels (<110 pg/ml). This specific loss of hypocretin and the strong association with the HLA-DQB1*06:02 allele led to the ...
Narcolepsy with cataplexy or narcolepsy type 1 in a rare, disabling sleep disorder, with a prevalence of 20 to 30 per 100,000. Its onset peaks in the second decade. The main features are excessive daytime sleepiness and cataplexy or sudden less of muscle tone triggered by emotional situations...
and 18 individuals were also evaluated by measures of cerebrospinal fluid hypocretin-1 concentration.None of the 29 girls and women showed signs of narcolepsy type 1.Our results do not suggest that an association exists between HPV vaccination and the development of narcolepsy type 1.none.not relev...
To ascertain whether the influence of the altered architecture of sleep in patients with narcolepsy type 1 (ie, with cataplexy: NT1) also varies with age, we compared the performance values of 16 children (aged from nine to 14 years) and 16 adults (aged from 24 to 51 years) on finger ...
T-cell reactivity to HCRT was also detected in type 2 narcolepsy, which is not associated with HCRT-deficiency30. Thus, the current literature on T cell reactivity to HCRT in NT1 remains conflicting. In many autoimmune diseases, autoimmunity is directed against multiple autoantigens expressed in...