Narcolepsy type INarcolepsy with cataplexy (NT1) is a chronic hypothalamic disorder with a presumed immune-mediated etiology leading to a loss of hypocretin neurons. Previous studies reported conflicting results in terms of presence of auto-antibodies involved in narcolepsy pathophysiology. A total of ...
Narcolepsy type 1 (NT1) is a chronic neurological disorder characterized by symptoms such as excessive daytime sleepiness, sudden sleep episodes, disrupted nocturnal sleep, cataplexy, sleep paralysis, and hypnagogic hallucinations, which significantly impact the overall well-being and quality of life of...
It has been shown that narcolepsy, a chronic and disabling disease, starts in childhood and adolescence rather than adulthood. The International Classification of Sleep Disorder (ICSD-3) classifies narcolepsy into Type 1 (narcolepsy with cataplexy) and Type 2 (narcolepsy without cataplexy). There ...
Narcolepsy with cataplexy or narcolepsy type 1 in a rare, disabling sleep disorder, with a prevalence of 20 to 30 per 100,000. Its onset peaks in the second decade. The main features are excessive daytime sleepiness and cataplexy or sudden less of muscle tone triggered by emotional situations...
Current general agreement considers the loss of hypothalamic hypocretin (orexin) neurons as the direct cause of narcolepsy notably cataplexy. To assess whether brain histamine (HA) is also involved, we quantified the cerebrospinal fluid (CSF) levels of HA and tele-methylhistamine (t-MeHA), the ...
To ascertain whether the influence of the altered architecture of sleep in patients with narcolepsy type 1 (ie, with cataplexy: NT1) also varies with age, we compared the performance values of 16 children (aged from nine to 14 years) and 16 adults (aged from 24 to 51 years) on finger ...
Narcolepsy type 1 (NT1) is a rare, chronic, neurological disease marked by symptoms that can significantly impact daily life1-3. These symptoms can include excessive daytime sleepiness, sudden loss of muscle tone (cataplexy) often triggered by strong emotions, disrupted nighttime sleep, temporary ...
Narcolepsy type 1 (NT1) is a rare, chronic brain disorder, characterized by excessive daytime sleepiness, cataplexy and disturbed nocturnal sleep1,2,3. An exceptionally high association of NT1 with the human leukocyte antigen (HLA) class II alleleDQB1*0602, and polymorphisms in the genes encodin...
Child and adolescent sleepiness is an important public health issue with potentially serious consequences on attention, learning, behaviour, and quality of... M Lecendreux,H Gamble,L Sanchez-Garrido,... - 《European Psychiatry》 被引量: 4发表: 2011年 Assessing narcolepsy with cataplexy in childre...
Narcolepsy type 1 (NT1), is a rare, chronic, and disabling neurological disease characterized by excessive daytime sleepiness, sudden loss of muscle tone (cataplexy) triggered by emotions, and fragmented nocturnal sleep [1,2]. NT1 is characterized pathologically by an almost complete and selective...