PROTAC TYK2 degrader-1 (CPD-155) 是一个 TYK2 的 PROTAC 靶向降解剂,Dmax >60%。(Srtucture Note: PINK, TYK2 ligand 1 (HY-158340); Blue, VHL ligand Thalidomide (HY-14658); Black, linker)更多产品详情查看:www.medchemexpress.cn/protac-tyk2-degrader-1.html PROTAC TYK2 degrader-1 | ...
DegraderJanus kinase (JAK)Proteolysis-targeting chimera (PROTAC)Tyrosine kinase 2 (TYK2)Von Hippel–Lindau (VHL)TYK2, a member of the JAK family of proximal membrane-bound tyrosine kinases, has emerged as an attractive target for the treatment of autoimmune diseases. Herein, we report the ...
Degrader 5 induced TYK2 degradation without affecting the protein level of subtype kinases (JAK1, JAK2, and JAK3) in Jurkat cellular assays. Furthermore, modifying the TYK2 ligand moiety of degrader 5 yielded the more potent TYK2 degrader 37 with retained selectivity for JAKs. Our subtype-...