T cells are critical for invasive insulitis, since protracted peri-insulitis occurs in NOD mice depleted of T cells by administration of antibodies directed against T cell surface markers (Charlton et al. 1988; Sempe et al. 1991; Chatenoud et al. 1994, 1997). Considerable evidence indicates ...
Chili pepper (Capsicum) is known for its unique fruit pungency due to the presence of capsaicinoids. The evolutionary history of capsaicinoid biosynthesis and the mechanism of their tissue specificity remain obscure due to the lack of high-qualityCapsicumgenomes. Here, we report two telomere-to-tel...
FOXO3 is consistently annotated as a human longevity gene. However, functional variants and underlying mechanisms for the association remain unknown. Here, we perform resequencing of the FOXO3 locus and single-nucleotide variant (SNV) genotyping in three
CD164 Monoclonal Antibodies That Block Hemopoietic Progenitor Cell Adhesion and Proliferation Interact with the First Mucin Domain of the CD164 Receptor The novel sialomucin, CD164, functions as both an adhesion receptor on human CD34+ cell subsets in bone marrow and as a potent negative regulator ...
A total of eight different isoforms of FLICE (caspase-8/a–h) have been described. To determine which isoforms are expressed in different cells we have generated a panel of monoclonal antibodies directed against all functional domains of FLICE. Using these antibodies we could show that only ...
This finding may be due to the differences in hCG isoforms the methods were measuring, as well as differences in reagent antibodies and the material used as calibrators. Whilst the equivalent recovery experiments initially showed overestimation, this was corrected once the average hematocrit proportion ...
The 54-kD protein of signal recognition particle contains a methionine-rich RNA binding domain. Signal recognition particle (SRP) plays the key role in targeting secretory proteins to the membrane of the endoplasmic reticulum (Walter, P., and V. R. Li... Romisch,K. - 《Journal of Cell Bi...
lyses virally infected cells or produce great amounts of antibodies that can directly neutralize the virus (IgM) or confer protection to a secondary homosubtypic influenza infection (IgA and IgG) (reviewed in [157]). CD4+and CD8+T cells have also been related to influenza immunopathology (re...
The representative gene functions and pathways were shown. e Heatmap showing expression of representative genes. Color key from blue to red indicates relative expression levels from low to high. f Heatmap of ALB + and ALB- specific genes (rows) and hierarchical clustering result in 34 S100...
antibodies Fig. 1: Sequence variation in spike glycoprotein. The open reading frame encoding spike (S) is illustrated, with the position of key features of processing and function indicated to approximate scale (residue number indicated above). During co-translational translocation to the endoplasmic ...