USA WEEKEND
Y190 (αleu2 trp1GAL-lacZ GAL-HIS3) and Y187 (aleu2 trp1GAL-lacZ) (Harperet al., 1993), which contain chromosomal copies of thelacZandHIS3genes under the regulation of the upstream activation sequence (UAS) recognized by Gal4p, were transformed with the resulting pGBT9- and pGAD424...
In order to demonstrate that the IR-1 element functions as an LXRE, we transfected cells with a TK-reporter gene under the control of two copies of the IR-1 from the PLTP promoter. This reporter gene was activated 5.3-fold by T0901317 in the presence of LXR/RXR, while the empty TK-...
Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3 (SCA3), is an autosomal dominant neurodegenerative disorder of late onset, which is caused by a CAG repeat expansion in the coding region of the ATXN3 gene. This disease presents clinical heterogeneity, which cannot be completely expl...
APOE genotype was also investigated: the first case results 4/3, the second 2/2; however, they shared a similar phenotype characterized by the presence of intermediate-density lipoproteins (IDL) remnant and the absence of lipoprotein-X. In conclusion, our findings suggest that APOE 2/2 may ...
The tail of LRP contains two copies of this motif, suggesting that the NPXY sequences might also function as endocytosis signals for LRP. In the present study, we provide direct evidence that the YXXL motif, but not the two NPXY motifs, serves as the dominant signal for LRP endocytosis....