We report that LDAM are more prevalent in AD brains compared to controls and enriched in individuals with the APOE4/4 genotype. This finding is confirmed by immunofluorescence for ACSL1, a key regulator of LD biogenesis, which may...
4. FangW, Xiao N, et al. APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline.Transl Psychiatry. 2021 Oct 05;11(1). DOI:10.1038/s41398-021-01631-0 5. ZhangJ, Lin L,...
Aging and APOE4 genotype are the strongest risk factors for Alzheimer's disease (AD), but how they affect microglial dynamics remains unclear. Using ex vivo confocal microscopy, we analyzed microglial dynamic behaviors in the entorhinal cortex (EC) and hippocampus CA1 of 6-, 12-, and 21-...
未来,有必要研究APOE4 R136S对Aβ病理以及小鼠模型认知的影响,以及阻断APOE4与HSPGs的结合,是否可以重现APOE4 R136S的效果。 治疗阿尔茨海默病的特效药,或许就藏在这个研究的背后。 参考文献: [1].Belloy ME, Andrews SJ, Le Guen Y, et al. APOE Genotype and Alzheimer Disease Risk Across Age, Sex, ...
这些发现可能导致靶向APOE的疗法来减缓或预防帕金森病患者的认知能力下降。相关研究结果发表在2020年2月5日的Science Translational Medicine期刊上,论文标题为“APOE genotype regulates pathology and disease progression in synucleinopathy”。 论文第一作者、华盛顿大学神经学助理教授Albert Davis博士说,“痴呆给帕金森病...
[3].Ossenkoppele R, van der Flier WM. APOE Genotype in the Era of Disease-Modifying Treatment With Monoclonal Antibodies Against Amyloid-β. JAMA Neurol. 2023. doi:10.1001/jamaneurol.2023.4046
The APOE4/4 genotype causes a lipid metabolic imbalance and has an impact on the development of AD. These insights may pave the way for targeted therapies against LD accumulation in microglia during the progression of AD. 展开 关键词: ANTI-Stokes scattering ALZHEIMER'S disease STAINS & staining...
这些发现可能导致靶向APOE的疗法来减缓或预防帕金森病患者的认知能力下降。相关研究结果发表在2020年2月5日的Science Translational Medicine期刊上,论文标题为“APOE genotype regulates pathology and disease progression in synucleinopathy”。 图片来自Science Translational Medicine, 2020, doi:10.1126/scitranslmed.aay...
Late-onset Alzheimer’s disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated gr
apolipoprotein e epsilon 4 (apoe‐ε4) genotype is associated with decreased 6‐month verbal memory performance after mild traumatic brain injury(载脂蛋白eε4(apoeε4)基因型与轻度脑外伤后6个月记忆功能下降相关) 文档格式: .pdf 文档大小: