In contrast, COX4 levels in APOE3 mice were reduced in the high-fat diet group. Our data show that diet and APOE genotype interact to produce adaptations in mitochondrial proteins in skeletal muscle.doi:10.1093/geroni/igab046.3496James Niaya...
MIND diet associated with reduced incidence of Alzheimer's disease Alzheimers Dement. (2015) R. Chouinard-Watkins Interaction between BMI and APOE genotype is associated with changes in the plasma long-chain-PUFA response to a fish-oil supplement in healthy participants Am. J. Clin. Nutr. (2015...
The APOE4 genotype is the greatest genetic risk factor increasing AD risk up to 15-fold compared with the common APOE3 genotype, while APOE2 is protective (3, 4), but less frequent [estimated: ε2/2 at 0.4%, ε2/3 at 8.8%, and ε2/4 at 1.5% (5, 6)]. Although this risk ...
ε3/4 genotype of the apolipoprotein E is associated with higher risk of Alzheimer's disease in patients with type 2 diabetes mellitus. The ε4 allele of the apolipoprotein E (ApoE) gene may be risk factor of severe peripheral neuropathy in T2DM patients. The association of ApoE ... Tang,...
In the peripheral immune system,APOEgenotype has been shown to modulate the level of C-reactive protein (CRP) in plasma or serum in multiple cohorts [126,127,128]. CRP is an inflammatory protein primarily produced by hepatocytes in response to injury or inflammation [129]. Interestingly,APOE4...
Apolipoprotein E (APOE) ɛ4 and low cerebrospinal fluid (CSF) amyloid-β42 (Aβ42) levels are predictors for developing Alzheimer’s disease (AD). The results of several studies indicate an interaction between docosahexaenoic acid (DHA) consumption and cognitive outcomes by APOE genotype. Our ...
而与 24 月龄 ApoE3 转基因小鼠相比,同龄 表 1 载脂蛋白 E 各亚型的生物学信息 Table 1 Biological information on subtypes of apolipoprotein E 碱基对 氨基酸 应位点 Amino 亚型 基因型 Base pair site acids Subtypes Genotype Rs429358 / Rs7412 112 158 分子量 ( ×103 ) Formula weight ( ×103 ) ...
In addition, using this ELISA, the apoE/Aβ complex is less stable at a low pH [4], also in agreement with previous data [66]. With the apoE/Aβ complex ELISA, we also identified an APOE genotype-specific difference in endogenous apoE/Aβ complex levels in EFAD-Tg mice and human ...
The lower affinity for the LDLR of apoE3 compared with apoE4 could then explain why increased receptor expression had no adverse effects with apoE3. CONCLUSIONS: Our results emphasize the occurrence of important and unexpected interactions between APOE genotype, LDLR expression, and diet. 展开 ...
APOE4 mice exhibited enhanced anti-tumor immune activation relative to APOE2 mice, and T cell depletion experiments showed that the effect of APOE genotype on melanoma progression was mediated by altered anti-tumor immunity. Consistently, patients with melanoma carrying the APOE4 variant experienced ...