To improve anti-TSA immunity while limiting anti-SSA autoreactivity, we need to understand how tumor-specific CD8+ T cells (TST) and SSA-specific CD8+ T (SST) cells differentiate in response to cognate antigens during tumorigenesis. Therefore, we developed a genetic cancer mouse model in ...
T. Duhen, R. Duhen, R. Montler et al., "Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors," Nature Communications, vol. 9, no. 1, p. 2724, 2018.Duhen, T. et al. Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T ...
Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria Jingwei Ma, Liang Tang, Yaoyao Tan, Jingxuan Xiao, Keke Wei, Xin Zhang, Yuan Ma, Shuai Tong, Jie Chen, Nannan Zhou, Li Yang, Zhang Lei, Yonggang Li, Jiadi Lv, Junwei...
Purpose: To evaluate whether patients with metastatic gastrointestinal adenocarcinomas refractory to chemotherapy harbor tumor-reactive cytotoxic T cells.Experimental Design: Expansion of CD8+ tumor-infiltrating lymphocytes (TIL) and cancer cell lines was attempted from gastrointestinal cancer metastases in 16 ...
Tumor-reactive CD8+ tumor-infiltrating lymphocytes (TILs) represent a subtype of T cells that can recognize and destroy tumor specifically. Understanding the regulatory mechanism of tumor-reactive CD8+ T cells has important therapeutic implications. Yet
We previously demonstrated the presence of tumor-reactive CD8 + T cells in PDAC samples. Here, we charted the tumor-infiltrating T cell repertoire in PDAC by combining single-cell transcriptomics with functional testing of T cell receptors (TCRs) for reactivity against autologous tumor cells. On ...
We sought to elucidate the impact of CTLA-4 expression on self/tumor-reactive CD8+ T cells by using the glycoprotein (gp) 100–specific T-cell receptor (TCR) transgenic mouse, pmel-1. pmel-1 CLTA-4–/– mice developed profound, accelerated autoimmune vitiligo. This enhanced autoimmunity was...
Then, we developed HBVs-CAR-T cells and found that CD39 may be associated with the killing effect of CAR-T cells. The HCC organoid-T cell co-culture system was constructed to verify the efficiency of CD39+ HBVs-CAR-T and CD39+ personalized tumor-reactive CD8+ T cells. Based on our ...
Therefore, the ability of a defined gamma9delta2TCR to redirect alphabetaT cells selectively against tumor cells was tested and its molecular interaction with a variety of targets investigated. Functional analysis revealed that a gamma9delta2TCR efficiently reprograms both CD4...
Tumor microenvironment (TME) is composed of diverse cell types whose interactions, both direct and indirect, significantly influence tumorigenesis and therapeutic outcomes. Within TME, reactive oxygen species (ROS) are produced by various cells and exhibit a dual role: moderate ROS levels promote tumor...