For more than two decades, tumor suppressor p53 has been among the most widely studied proteins. Notably, the myriad cellular functions in which p53 is involved continue to increase (Levine et al. 2006; Efeyan and Serrano 2007; Fuster et al. 2007). The human p53 protein consists of 393 ...
The p53 tumor suppressor protein is a transcription factor with sequence-specific DNA binding activity regulating gene expression related to multiple cellular functions including, but not limited to, cell cycle arrest, cell apoptosis, cell growth, DNA repair, cell metabolism, and the immune response ...
variants or tumor-suppressor gene : any of a class of genes (as p53 and APC) that act in normal cells to inhibit unrestrained cell division and that when inactivated (as by mutation) place the cell at increased risk for malignant proliferation In some cases [of cancer], growth-inhibiting...
p53 (Tumor Suppressor Protein) p53 (Tumor Suppressor Protein)(p53 (Tumor Suppressor Protein)) CAS: 化学式: 主页 产品 p53 (Tumor Suppressor Protein) 中文名p53 (Tumor Suppressor Protein) 英文名p53 (Tumor Suppressor Protein) 英文别名p53 (Tumor Suppressor Protein)...
1. Introduction ING1 (inhibitor of growth1) protein functions as a type II tumor suppressor which plays a significant role in multiple cellular activities such as growth regulation, DNA repair, apoptosis and senescence [1]. ING1 gene was cloned in 1996 [2], and several years later, its iso...
Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kapp... Transcription factor and are two suppressors that play essential roles in suppression of . However, the mechanisms by which mediates anticancer ...
6) Tumor suppressor protein p14ARF 肿瘤抑制蛋白质p14ARF补充资料:肿瘤抑制基因 分子式:CAS号:性质:是一类肿瘤抑制基因的总称。第一个分离到的抑癌基因是Rb基因(retinoblastoma gene)或称视网膜母细胞瘤基因。现已证明:结肠癌等多种癌症也检出Rb基因的缺陷。已被证实的抑癌基因有10多种,都是通过缺失或失活而...
p53 (Tumor Suppressor Protein, Oncogene Protein) (Biotin) E structure CAS No. Chemical Name: p53 (Tumor Suppressor Protein, Oncogene Protein) (Biotin) E Synonyms p53 (Tumor Suppressor Protein, Oncogene Protein) (Biotin) E CBNumber: CB7997622 Molecular Formula: Molecular Weight: 0 MDL...
Functional loss of tumor suppressor protein p53 is a common feature in diverse human cancers. The ability of this protein to sense cellular damage and halt the progression of the cell cycle or direct the cells to apoptosis is essential in preventing tumorigenesis. Tumors having wild-type p53 also...
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