Full size image Discussion Thrombocytosis and anemia are common in individuals with cancer1,45. Here we identified a tumor release factor-mediated pathway that causes thrombocytosis and anemia. During tumor growth, large amounts of Kyn are released to the periphery, enter MEPs and bias their differ...
Full size image In summary, we elucidated an emerging functionality of SPHK1, identified SPHK1-mediated immunosuppression established by transcriptional regulation of PD-L1 in malignant melanoma and demonstrated a novel mechanism of PD-L1 expression. Importantly, the SPHK1-MTA3 axis holds the potential...
Full size image However, CAF-rich tumors also show resistance to immunotherapy by the exclusion of CD8+T cells through the secretion of chemokines. CAF inhibits TNF- and IFN-induced T cell-mediated necrosis and promotes immunosuppression by activating NF-κB signaling through the secretion of IL-6...
Tisdale MJ, Brennan RA, Fearon KC (1987) Reduction of weight loss and tumour size in a cachexia model by a high fat diet. Br J Cancer 56(1):39–43. https://doi.org/10.1038/bjc.1987.149 Article CAS PubMed PubMed Central Google Scholar Torti SV, Torti FM (2011) Ironing out cancer...
Sign in to download full-size image Fig. 1.Schematic representation of the nucleosomal organization of the mouse mammary tumor virus (MMTV) LTR. When stably introduced into cells, the MMTV promoter organizes into a phased array of nucleosomes, labeled A to F. High-resolution mapping of th...
Shredding of proteins within the cytoplasm by the proteasome (specifically, a proteasomal complex induced by IFN-γ called "immunoproteasome", which is primarily responsible for the degradation of proteins into peptides that are optimal in size for MHC binding), Transportation of the peptides to ...
A) Reduction in tumor size on treatment with MK-2206. B) Reduction in tumor volume in treated animals as compared to control animals. C) Reduction in the average tumor volume in animals treated with MK-2206 as compared to control animals. D) Reduction in tumor weight on treatment with Akt...
Download: Download full-size image Figure 4. TA-HEVs are the main sites of lymphocyte tethering, rolling, and sticking in the tumor microcirculation (A–F) Intravital microscopy analyses of TA-HEVs in MCAprog tumors from mice not treated (NT, day 8) or treated with ICB (anti-CTLA-4 +...
Full size image CellTrek is a computational toolkit that enables direct mapping of individual cells back to their spatial coordinates in tissue sections based on scRNA-seq and ST data [14]. Unlike ST deconvolution methods, this approach transferred ST coordinates to single cells, thereby achieving ...
Full size image ecDNA-amplified enhancers modulate oncogene transcription To test whether co-amplified enhancers on ecDNA have functional roles in tumor cell proliferation, we performed a pooled CRISPRi proliferation screen in the Group 3 medulloblastoma cell line D458, targeting all 645 accessible loci...