Tisdale MJ, Brennan RA, Fearon KC (1987) Reduction of weight loss and tumour size in a cachexia model by a high fat diet. Br J Cancer 56(1):39–43. https://doi.org/10.1038/bjc.1987.149 Article CAS PubMed PubMed Central Google Scholar Torti SV, Torti FM (2011) Ironing out cancer...
microenvironment by upregulating PD-L1 expression in carcinoma cells [58,59,60]. EGFR and JAK/STAT signaling, associated with the “undifferentiated” signature, and PI3K signaling, associated with the “alveolar/club-like” signature, are potential therapeutic targets [4,60,61]. We identified canc...
Full size image AhR promotes MEP differentiation into megakaryocytes Next, we determined whether AhR plays a role in MEP differentiation. The genes encoding cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) and cytochrome P450 family 1 subfamily B polypeptide 1 (CYP1B1) are AhR-targete...
Full size image MiR-141 induces stromal fibroblasts to have CAF-like properties Intriguingly, enforced expression of miR-141 in stromal cells mimicked the effect of exosomal miR-141 in tumor-stromal interactions, and the XTT cell proliferation assay showed that the miR-141 stromal cell conditioned...
Download: Download full-size image Figure 1. Ectosomal PKM2 Induces Monocyte Differentiation In this figure, THP-1 cells were incubated with ectosomes (10 μg/mL) from Huh7 cells (Scramble) or PKM2 KD Huh7 cells with or without 2-DG treatment (10 mM) for 3 days, unless specially defined...
Full size image Transcriptional signature of the adultbratk06028mutant brain tumor In order to gain insights into the genetic alterations associated with a fully developed brain tumorin vivo, we determined at the full genome level the transcriptome of the neoplastic brain tumors caused by homozygousbr...
Full size image In human melanoma patients, anti-PD-1 therapeutic responses were reported to be associated with the presence of PD-1 expressing CD8+ T cells at the tumor margin, co-localized with PD-L1 expressing tumor cells before therapy [21], and therefore PD-1+ CD8+ T cells can be...
infusion of tumor-specific CTLs identified by CDR3-size spectratype analysis was shown to induce a significant GVT response, but the same tumor-reactive Vβ family, which initially showed no hematopoietic alloreactivity was ultimately the causal entity of gut pathology in recipient mice, when admi...
Full size table Zinc deficiency adversely affects lymphocyte proliferation. Zinc deficient conditions are associated with elevated glucocorticoids, which cause thymic atrophy and accelerate apoptosis in thymocytes, thereby reducing lymphopoiesis [50,51]. In murine studies, zinc-deficient diets cause substantial...
The coating of the pie-like CCM on IDINPs enlarged the size of the nanosystem to 96.9 nm (Fig. 1b) and shifted the zeta potential to −15.0 mV (Fig. S1a). The results of an elemental composition study (Fig. 1c) showed that the elements P, S, and Ca in CCM were ...