The lung is one of the most sensitive tissues to ionizing radiation, thus, radiation-induced lung injury (RILI) stays a key dose-limiting factor of thoracic radiotherapy. However, there is still little progress in the effective treatment of RILI. Ras-related C3 botulinum toxin substrate1, Rac1...
Full size image AhR promotes MEP differentiation into megakaryocytes Next, we determined whether AhR plays a role in MEP differentiation. The genes encoding cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) and cytochrome P450 family 1 subfamily B polypeptide 1 (CYP1B1) are AhR-targete...
Full size image MiR-141 induces stromal fibroblasts to have CAF-like properties Intriguingly, enforced expression of miR-141 in stromal cells mimicked the effect of exosomal miR-141 in tumor-stromal interactions, and the XTT cell proliferation assay showed that the miR-141 stromal cell conditioned...
arrowheads). In paraffin sections the size of the central brain structures and the optic lobes ofbratk06028mutants appeared reduced as compared to the wildtype, however, the overall morphology of neuropil subdivisions in these brains was retained. ...
The mouse body weight and tumor size were measured at different time points following tumor implantation, and the tumor volume was calculated according to the following formula: 1/2 (Length × Width2). The tumors were removed at Day 36 after tumor implantation, photographed, and weighed. The ...
Table 2 Mean pre-chemotherapy counts/mm 2 of tumor infiltrating lymphocytes subpopulations and CD68 for the whole group of patients and comparison between responding and non-responding patients Full size table In order to understand better the complexity of immune subpopulation profiles in breast ...
likely reflecting the glycolytic activity of the tumor cells and thus acidity within the tumor microenvironment, turned out to be one of the strongest markers predicting response to checkpoint inhibition. In this review, we discuss the impact of tumor-associated acidity on the efficacy of T cell-...
DownLoad: Full-Size Img PowerPoint Figure 2. Tumor weights in nude mice transplantation tumors during treatment with LFBE (high-dose 2 g·kg-1·d-1, low-dose 1 g·kg-1·d-1) and 5-FU (25 mg·kg-1·d-1). On day 30: the mice were sacrificed and the tumor weights were measure...
Abstract C169: MM-141, a bispecific antibody inhibitor of PI3K/AKT/mTOR, attenuates tumor growth and potentiates everolimus in mouse models of anti-hormona... Abstract C169: MM-141, a bispecific antibody inhibitor of PI3K/AKT/mTOR, attenuates tumor growth and potentiates everolimus in mouse ...
Full size image Formo suppresses EGFR signaling ex vivo and in vitro To determine the anti-tumor mechanisms of Formo, we first examined the effect of Formo on EGFR signaling. Using the in vitro pulldown assay, we analyzed the interaction between Formo and EGFR WT/activating mutants (Del E7...