Guichelaar T, Mutis T. Bone marrow provides an environment that pre- vents suppression of therapeutic graft-vs.-tumor immunity by regulatory T cells. Oncoimmunology 2013;2:e24659.Guichelaar T, Mutis T. Bone marrow provides an environment that prevents suppression of therapeutic graft-vs.-tumor...
Leukemia is a cancer that begins in blood-forming tissue, such as the bone marrow, and causes too many abnormal blood cells to be made. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissue...
IDH wt) is the most aggressive type of cancer with one of the worst prognoses, due to the lack of effective therapies [37]. Diffuse gliomas are histologically classified as low and intermediate-grade gliomas (grades II and III) (herein called Lower-Grade Gliomas, LGG) or glioblastomas (GBM...
This process has been demonstrated to occur at tumor site, but also in local or distant immune districts, such as draining lymph nodes or the bone marrow, suggesting the presence of factors capable of molding immune responses at systemic level. Soluble molecules or circulating tumor-related cells...
preferential growth of bacteria in tumors5. The first generation of bacterial therapy used natural, live bacteria, inactivated or deactivated, to treat tumors1,2. One successful example is Bacillus Calmette-Guérin (BCG), composed of liveMycobacterium tuberculosis, for the treatment of bladder cancer...
This LOD is several times better than PSA concentration in human serum associated with a high risk of prostate cancer (from 10 ng/mL) and so-called “grey zone” (4–10 ng/mL) when additional research methods must be used for the diagnosis. But that was not it, further analyses with ...
The tumor microenvironment (TME) is a highly intricate milieu, comprising a multitude of components, including immune cells and stromal cells, that exert a profound influence on tumor initiation and progression. Within the TME, angiogenesis is predominan
T cells are specific to the mutant proteins of cancer cells. Interestingly, these cells could be extracted from a patient’s tumor tissue. After amplification in vitro, they are injected back into the patient, producing a long-lasting antitumor response. However, the method is mainly used for ...
Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote tum
Despite the advancements made in the diagnosis and treatment of cancer, the stages associated with metastasis remain largely incurable and represent the primary cause of cancer-related deaths. The dissemination of cancer is facilitated by circulating tum