Tumor marker refers to a class of secretions produced by the body in response to tumor stimulation, which can indicate the presence of a tumor and monitor the immune response of the organism. From: Electrochemistry Communications, 2021 About this pageSet alert Also in subject areas: Agricultural ...
Seven serological tumor biomarkers (CEA, CA19-9, CA242, CA72-4, CA50, CA125, and AFP) are routinely adopted in clinical practice to assist diagnoses and determine prognosis in gastroenterological cancers at our institute. The most common and best-studied biomarker for CRC is CEA, which can b...
Aiming to assess blood TMB (bTMB) prospectively, we conducted B-F1RST (NCT02848651), an open-label, phase 2 trial that evaluated bTMB as a predictive biomarker for first-line atezolizumab monotherapy in locally advanced or metastatic stage IIIB–IVB non-small cell lung cancer (n = 152)...
Once a potential marker is identified by this technique, an important next step is its validation and introduction in routine tests in hospital settings.5, 6 There, cDNA arrays are not the method of choice because they are still expensive, time-consuming, complex, and require frozen material no...
Tumor mutational burden (TMB) serves as a widely recognized biomarker for immunotherapy and is generally associated with patients' response to ICB [50,51]. Therefore, we conducted a comprehensive analysis using data from TCGA database focusing on melanoma patients. Surprisingly, we found that melanom...
(iii) Gene therapy. Sequencing MTSs could give some clues for gene therapy; (iv) Clinical biomarker. It could provide sufficient in vitro cancer models to establish different models in individual tumors to study tumor metabolism, and find markers for clinical tumor screening; (v) Tumor invasion ...
We also compared the accuracy of ctDNA, a novel but relatively costly blood biomarker, with that of the standard CEA test that is widely used in the clinic to estimate recurrence. The Kaplan-Meier model outputs for these 2 tests demonstrated a slightly higher HR for postsurgical ctDNA (3.8)...
DR RUGO: I think it’s so exciting for us to find a marker we can treat in breast cancer outside of ER, PR and HER2 and one where there’s some data as well. And I think really when I say to people, “Are you going to do sequencing,” or you send it, really what you’re...
Since aberrant DNA methylation occurs very early during tumorigenesis, it could, therefore be used as an early diagnostic marker (Bhat et al. 2016; Das and Singal 2004; Karayan-Tapon et al. 2010; Wentzensen et al. 2009). The panel of distinct CpG sites identified in our study was found...
A tumor marker, also called marker or biomarker, is a substance sometimes found in an increased amount in the blood, other body fluids, or tissues and which may mean that a certain type of cancer is in the body. There are many different tumor markers, each indicative of a particular disea...