Regulated cell deathimmunogenic cell deathcancer immunosurveillanceoncogenetumor suppressorThe immune system can recognize tumor cells to mount antigen-specific T cell response. Central to the establishment of T cell-mediated adaptive immunity are the inflammatory events that facilitate antigen presentation by...
eIF2α phosphorylation is pathognomonic for immunogenic cell death. Cell Death Differ. 25, 1375–1393 (2018). Article CAS PubMed PubMed Central Google Scholar Song, M. et al. IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity. Nature 562, 423–428...
production by down-regulating transforming TGF-β and activating an immune response through the induction of tumor cell immunogenic cell death (ICD). Zhang et al.187found that mitochondria-anchoring self-assembled nanoparticles (BLG@TPGS NPs) significantly inhibit TNBC metastasis by targeting mitochondria...
2.3.3Immunogenic cell death CONV-RT can both induce tumor cell death and modulate tumorimmunogenicity.96First, CONV-RT modulates immunogenicityviapresentingtumor antigen, called “immunogenic”. IR converts the tumor tissue into anin situvaccine eliciting tumor-specificT cellsand endowing the host wit...
The high redox level of tumor microenvironment inhibits the oxidation treatment and the immune response. Here, we innovatively develop maleimide liposome (ML) adjuvants to promote immunogenic cell death (ICD) induction and dendritic cells (DCs) maturation by glutathione (GSH) depletion for augmenting ...
Immunogenic cell death is characterized by damage-associated molecular patterns, which can enhance the maturation and antigen uptake of dendritic cells. Shikonin, an anti-inflammatory and antitumor phytochemical, was exploited here as an adjuvant for dendritic cell-based cancer vaccines via induction of ...
In agreement with this finding, the high-expression group also had a significantly low immunogenic cell death pathway score. The functional consequence of high PRKAA2 expression was increased immune escape (Fig. 5E). Fig. 5 PRKAA2 is associated with the immune escape of tumor cells. A The ...
Induction of immunogenic tumor cell death by attenuated oncolytic measlesAuthor(s): Publication date: 2015 Journal: Virus Read this article at ScienceOpen Bookmark There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more ...
immunogenic cell death (ICD) characterized by the release of HMGB1 and HSP70 [20,117]. In addition, the supernatant of hypofractionated irradiated tumor cells elevated the percentage of migrating DCs and raised the activation markers CD80 and CD86 expression. The number of infiltrating intratumoral ...
the cell may enter a state of cellular senescence or undergo processes related to immunogenic cell death (ICD),1such as necroptosis, ferroptosis and pyroptosis.13,14Senescent cancer cells can still survive but permanently stop growing and cannot reenter the cell cycle, which seems to be beneficial...