Cell Death Research & Therapy (CDRT) unit, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.Dirk.De RuysscherMaastricht University Medical Center, Department of Radiation Oncology (MAASTRO Clinic), GROW-School for Oncology and Developmental Biology, Maastricht, Netherlands....
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Detection of immunogenic cell death and its relevance for cancer therapy. Cell Death Dis. 2020;11:1013. Article CAS PubMed PubMed Central Google Scholar Galluzzi L, Humeau J, Buqué A, Zitvogel L, Kroemer G. Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors. Nat...
The chemokine gradient attracts effector T cells to irradiated tumor with the promotion of vascular cell adhesion molecule (VCAM)-1, and the increased expression of major NDDSs-based combinatorial regimens Combination use of chemotherapy and physical therapy (including phototherapy and radiotherapy) with...
Trial watch: Chemotherapy with immunogenic cell death inducers. Oncoimmunology 2013 ; 2:e23510; http://dx.doi.org/ 10.4161/onci.23510 ; PMID: 23687621... E Vacchelli,A Eggermont,C Sautès-Fridman,... - 《Oncoimmunology》 被引量: 368发表: 2013年 Molecular mechanisms of ATP secretion during...
Chemotherapy, radiation therapy, as well as targeted anticancer agents can induce clinically relevant tumor-targeting immune responses, which critically rely on the antigenicity of malignant cells and their capacity to generate adjuvant signals. In particular, immunogenic cell death (ICD) is accompanied ...
PT-112 is a novel immunogenic cell death (ICD)-inducing small molecule currently under Phase 2 clinical development, including in metastatic castration-resistant prostate cancer (mCRPC), an immunologically cold and heterogeneous disease state in need of
chemotherapy119. Of note, the cell death-associated secretion of ATP resembles HGMB1 release in that it can also accompany non-immunogenic variants of cell death. At least in vitro, however, normalizing extracellular ATP levels to percentage of dead cells or to the ATP plateau that can be ...
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