blood samples from enrolled patients. Upon immunofluorescence analysis, the enriched cells showed positive markers for EpCAM, TTF-1, synaptophysin and negative for CD45. Additionally, the expanded CTCs demonstrated marked heterogeneity in the expression of E-cadherin and N-cadherin. In a prelim...
Journal of Otolaryngology - Head and Neck Surgery (2017) 46:17 Page 4 of 4 While a dual population of cells on cytology may al- lude to an intra-tumor metastasis, immunohistochemis- try can fortify a working diagnosis. Specific markers such as TTF1 which is found in the lung and ...
The tumor cells were immunpositive for cytokeratin (CK), CK7, epithelial membrane antigen, carcinoembryonic antigen and showed diffuse and strong nuclear positivity for thyroid transcription factor 1. They were negative for neuroendocrine markers and pituitary hormones. Ki-67 proliferation index was low ...
The majority of tumor cells were positive for CK7, synaptophysin, E-cadherin, and rarely for CK20 and D2-40. Tumor cells were negative for EMA, transthyretin, myogenin, desmin, progesterone receptor, NeuN, Olig-2, TTF-1, GATA3, PAX8, OCT3/4, SALL4, CD117, S100 and GFAP. Vasculature...
While a dual population of cells on cytology may allude to an intra-tumor metastasis, immunohistochemistry can fortify a working diagnosis. Specific markers such as TTF1 which is found in the lung and thyroid gland, and thyroglobulin all support the classification of WDTC [1, 6]. Although both...
DCIS cells were treated with vehicle (ethanol) or E2 (1 nM E2) together with a progestin agonist (10 nM R5020 (17 alpha, 21-dimethyl-19-nor-pregna-4, 9-diene-3,20-dione)) for either 6 or 24 hours in triplicate experimental cultures. Cell lysates were prepared and spotted on slides...
positive for the human papillomavirus 18 (HPV 18)11. As an unusual HPV-associated neuroendocrine tumor, SCNECC may comprise heterogeneous cells in the tumor microenvironment (TME)12,13,14,15,16,17; however, RNA sequencing data provide only the average gene expression for all cells rather than ...
Lung cancer is the leading cause of cancer-related death worldwide. We previously found that Mediator complex subunit 23 (MED23) is important for the tumourigenicity of lung cancer cells with hyperactive Ras activity in vitro, although the in vivo functi
Moreover, MYC did not only promote the progression of PCa, but also led to immunosuppression in TME by regulating PDL1 and CD47. The proportion of CD8 + T cells in TME and among NK cells and monocytes was lower in LNM than in the primary lesion, while the opposite was true for ...
(circular) tubules correspond to Sertoli cells, but contain false lumens. They also contain histologic elements consistent with GCTs, and they secrete estradiol. As in GCTs, estradiol is not a useful tumor marker, but inhibin may be useful for surveillance purposes. Progesterone levels also prove...