However, tumor-associated macrophage, which are enriched in tumors, plays an important role in the development of GBM and is becoming a research hotspot for immunotherapy. This review focuses on current research advances in the use of macrophages as therapeutic targets or therapeutic tools for ...
The exploration of tumor-associated neutrophil extracellular traps (NETs) within the tumor microenvironment has garnered significant interest recently. Originally identified as part of the body’s antimicrobial defense, NETs are now understood to significantly influence tumor progression by promoting angiogenes...
neutrophil infiltration in PCa is correlated with an unfavorable prognosis and decreased response to antineoplastic treatment. This was suggested in a study by Meisel et al., which demonstrated that a reduced neutrophil-to-lymphocyte ratio and a grade ≥3 are associated with longer OS and doubled ...
According to KEGG analysis, pathways related to neutrophil extracellular trap formation, toll-like receptor signaling pathway, and lipid and atherosclerosis were strongly associated with the NETRGs (Fig. 1F, Supplemental Table 3). 3.2. NETs-related classification based on the prognostic NETRGs A ...
[47]. Also, cAMP may inhibit NETosis, a type of neutrophil cell death associated with the release of neutrophil extracellular traps (NETs) [48]. Ferroptosis is another type of programmed cell death triggered by labile iron and lipid peroxidation. PKA had both pro-ferroptosis and anti-...
Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and the immunosuppressive nature of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components of the TME.
indicating the increasing evasion of immune attack during this neuroendocrine differentiation process. The malignant cells of intermediate state showed double-negative signatures for DGC and NEC marker genes, representing a possible “stem/progenitor cell” signature that might be associated with gastric can...
found that glioma patients with higher levels of neutrophils or neutrophil to lymphocyte ratios were more likely to have poor prognosis [25]. Neutrophil extracellular traps (NETs), produced by tumor-infiltrating neutrophils (TINs), are an oncogenic marker of high-grade gliomas (HGGs) and promote ...
metastasis and that interventions targeting the “HMGB1-CD62Ldimneutrophil-NETs” axis could inhibit lung metastasis. Our results suggest that the combination of HMGB1 and CD62Ldimneutrophils is a potential marker for breast cancer lung metastasis and is novel target for future prevention and therapy...
Immunosuppressive cells residing in the tumor microenvironment, especially tumor associated macrophages (TAMs), hinder the infiltration and activation of T cells, limiting the anti-cancer outcomes of immune checkpoint blockade. Here, we report a biocompa